CRCGN016_MCF10A.WT.HP_24H:F12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description eugenol 11.16 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

66 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:F12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGR2 anterior gradient 2 6.6884
E2F2 E2F transcription factor 2 5.7125
MYLK myosin light chain kinase 5.51025
MAP7 microtubule-associated protein 7 5.1711
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.9614
COMP cartilage oligomeric matrix protein 4.4911
PDIA5 protein disulfide isomerase family A, member 5 3.27625
RAB31 RAB31, member RAS oncogene family 3.11307
WDR7 WD repeat domain 7 2.8719
ACTG2 actin, gamma 2, smooth muscle, enteric 2.63155
BACE2 beta-site APP-cleaving enzyme 2 2.6154
NTM neurotrimin 2.3446
WASF2 WAS protein family, member 2 2.3298
ATP5F1A ATP synthase F1 subunit alpha 2.27535
CASQ2 calsequestrin 2 (cardiac muscle) 2.26805
POPDC2 popeye domain containing 2 2.1816
MYH11 myosin, heavy chain 11, smooth muscle 2.1255
SLK STE20-like kinase 2.1132
IBSP integrin-binding sialoprotein 2.1112
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.10895
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 2.09105
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 2.0789
OLFML2B olfactomedin-like 2B 2.05815
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.0567
ZBTB16 zinc finger and BTB domain containing 16 2.0545
CAVIN2 caveolae associated protein 2 2.03855
SORBS3 sorbin and SH3 domain containing 3 2.03067
MMP1 matrix metallopeptidase 1 2.0222
SIM2 single-minded family bHLH transcription factor 2 2.01067
CETP cholesteryl ester transfer protein, plasma 2.00705

decreased expression

Symbol Name Standardized Value
COG2 component of oligomeric golgi complex 2 -5.18415
RNF167 ring finger protein 167 -5.1103
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.9719
GDF15 growth differentiation factor 15 -4.8233
CHIC2 cysteine-rich hydrophobic domain 2 -4.7923
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.7915
KRT14 keratin 14, type I -4.76195
PRPF4 pre-mRNA processing factor 4 -4.61947
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -3.92245
TIMP1 TIMP metallopeptidase inhibitor 1 -2.80625
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 -2.70165
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3 -2.5302
ARID4B AT rich interactive domain 4B (RBP1-like) -2.37745
SLC31A1 solute carrier family 31 (copper transporter), member 1 -2.33575
DEFB1 defensin, beta 1 -2.28505
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 -2.27395
STK38 serine/threonine kinase 38 -2.2464
AMPH amphiphysin -2.2317
GPATCH2 G patch domain containing 2 -2.19775
FLG filaggrin -2.1915
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 -2.1732
MTMR14 myotubularin related protein 14 -2.1725
FKBP15 FK506 binding protein 15, 133kDa -2.17073
LZTS3 leucine zipper, putative tumor suppressor family member 3 -2.1449
RNF5 ring finger protein 5, E3 ubiquitin protein ligase -2.1322
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 -2.10205
TMEM184C transmembrane protein 184C -2.06595
TTC13 tetratricopeptide repeat domain 13 -2.0643
BCL9 B-cell CLL/lymphoma 9 -2.046
MARK1 MAP/microtubule affinity-regulating kinase 1 -2.03845
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 -2.03695
SDF2 stromal cell-derived factor 2 -2.0323
TBCCD1 TBCC domain containing 1 -2.02725
KRT2 keratin 2, type II -2.0252
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 -2.01587
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -2.0027