CRCGN016_MCF10A.WT.HP_24H:F18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description BRD-K88965984 11.22 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

49 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:F18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 4.07866
ACAA1 acetyl-CoA acyltransferase 1 3.89152
BTK Bruton agammaglobulinemia tyrosine kinase 3.22067
SPAG4 sperm associated antigen 4 3.15687
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 3.14485
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.03055
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.91197
EIF4H eukaryotic translation initiation factor 4H 2.67877
HBA1 hemoglobin, alpha 1 2.59739
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.51442
KDM5A lysine (K)-specific demethylase 5A 2.27538
AGR2 anterior gradient 2 2.22762
NBPF3 neuroblastoma breakpoint family, member 3 2.19209
WBP11 WW domain binding protein 11 2.13924
GET1 guided entry of tail-anchored proteins factor 1 2.12399
TSPYL4 TSPY-like 4 2.11841
SRSF9 serine/arginine-rich splicing factor 9 2.08319
EGR1 early growth response 1 2.06196
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 2.05225

decreased expression

Symbol Name Standardized Value
STXBP2 syntaxin binding protein 2 -5.16378
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -4.51077
BASP1 brain abundant, membrane attached signal protein 1 -4.21357
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.92452
TXNDC9 thioredoxin domain containing 9 -3.7038
TRAPPC3 trafficking protein particle complex 3 -3.35278
CD58 CD58 molecule -3.20281
MAP7D1 MAP7 domain containing 1 -2.96477
GDF15 growth differentiation factor 15 -2.82437
DSG2 desmoglein 2 -2.81517
NME6 NME/NM23 nucleoside diphosphate kinase 6 -2.65294
ZNF430 zinc finger protein 430 -2.4085
SCAND1 SCAN domain containing 1 -2.37024
MRPS15 mitochondrial ribosomal protein S15 -2.36147
RRAGC Ras-related GTP binding C -2.32843
S100A8 S100 calcium binding protein A8 -2.28056
NT5DC2 5'-nucleotidase domain containing 2 -2.24079
COQ10B coenzyme Q10 homolog B (S. cerevisiae) -2.23914
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -2.22103
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative) -2.19104
TRIB3 tribbles pseudokinase 3 -2.18888
KIAA0319L KIAA0319-like -2.14046
CUTA cutA divalent cation tolerance homolog (E. coli) -2.12589
UNC50 unc-50 homolog (C. elegans) -2.12317
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived) -2.11416
NRIP1 nuclear receptor interacting protein 1 -2.10318
ACTR10 actin-related protein 10 homolog (S. cerevisiae) -2.05788
ZFAND1 zinc finger, AN1-type domain 1 -2.01011
RAX retina and anterior neural fold homeobox -2.00754
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) -2.0048