CRCGN016_MCF10A.WT.HP_24H:F21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description benzo(a)pyrene 10.77 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

56 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:F21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CARMIL1 capping protein regulator and myosin 1 linker 1 4.80403
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 3.12337
CDPF1 cysteine-rich, DPF motif domain containing 1 3.12233
HBA1 hemoglobin, alpha 1 2.90626
IGHMBP2 immunoglobulin mu binding protein 2 2.82122
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.67234
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.65623
TSPAN6 tetraspanin 6 2.58482
FBXO11 F-box protein 11 2.3771
GRB10 growth factor receptor-bound protein 10 2.31427
MAPKAP1 mitogen-activated protein kinase associated protein 1 2.28093
INPP1 inositol polyphosphate-1-phosphatase 2.18258
GATA2 GATA binding protein 2 2.13337
IL1B interleukin 1, beta 2.08135
ZFAND5 zinc finger, AN1-type domain 5 2.05634
RANBP9 RAN binding protein 9 2.04752
CDC25B cell division cycle 25B 2.02456

decreased expression

Symbol Name Standardized Value
CCNB1 cyclin B1 -4.43509
CD320 CD320 molecule -4.20648
PCNA proliferating cell nuclear antigen -4.15183
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.13084
RNF167 ring finger protein 167 -4.0352
C1QBP complement component 1, q subcomponent binding protein -3.82678
CCDC86 coiled-coil domain containing 86 -3.70196
GTPBP8 GTP-binding protein 8 (putative) -3.57129
SLC35F2 solute carrier family 35, member F2 -3.4381
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.30848
LYPLA1 lysophospholipase I -2.85954
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.53777
CTSB cathepsin B -2.48561
DDRGK1 DDRGK domain containing 1 -2.47796
ACP5 acid phosphatase 5, tartrate resistant -2.44919
ATP5F1E ATP synthase F1 subunit epsilon -2.4272
TAOK1 TAO kinase 1 -2.42389
PLAAT3 phospholipase A and acyltransferase 3 -2.37935
SCYL3 SCY1-like 3 (S. cerevisiae) -2.37256
GGTLC1 gamma-glutamyltransferase light chain 1 -2.3454
PFN1 profilin 1 -2.32098
RNF125 ring finger protein 125, E3 ubiquitin protein ligase -2.31564
MSN moesin -2.30176
FLCN folliculin -2.27773
CKLF-CMTM1 CKLF-CMTM1 readthrough -2.25878
IGFLR1 IGF-like family receptor 1 -2.2523
CD7 CD7 molecule -2.24584
B3GAT1 beta-1,3-glucuronyltransferase 1 -2.24304
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3 -2.21766
MAGT1 magnesium transporter 1 -2.20762
MT1X metallothionein 1X -2.15087
UFM1 ubiquitin-fold modifier 1 -2.13811
PLAAT4 phospholipase A and acyltransferase 4 -2.13144
TMSB15C thymosin beta 15C -2.0972
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -2.03431
AP5S1 adaptor-related protein complex 5, sigma 1 subunit -2.02841
PANK2 pantothenate kinase 2 -2.0261
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -2.02463
CERT1 ceramide transporter 1 -2.01813