CRCGN016_MCF10A.WT.HP_24H:F22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-methylaniline 100.61 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

40 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:F22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UGDH UDP-glucose 6-dehydrogenase 3.58
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 3.48007
MKNK1 MAP kinase interacting serine/threonine kinase 1 3.36966
PDLIM1 PDZ and LIM domain 1 3.03821
KLHL21 kelch-like family member 21 2.86566
CRELD2 cysteine-rich with EGF-like domains 2 2.85163
GCLC glutamate-cysteine ligase, catalytic subunit 2.72663
GADD45A growth arrest and DNA-damage-inducible, alpha 2.56742
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.43153
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 2.24677
COPS7A COP9 signalosome subunit 7A 2.19096
RASAL2 RAS protein activator like 2 2.1716
MFSD1 major facilitator superfamily domain containing 1 2.15048
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 2.02317

decreased expression

Symbol Name Standardized Value
HSPA8 heat shock 70kDa protein 8 -5.41202
ACOT9 acyl-CoA thioesterase 9 -5.1912
SLC35F2 solute carrier family 35, member F2 -5.16863
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.74406
S100A8 S100 calcium binding protein A8 -4.02032
HAT1 histone acetyltransferase 1 -3.56531
GDF15 growth differentiation factor 15 -3.45015
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.12873
PRDX4 peroxiredoxin 4 -2.81052
CANT1 calcium activated nucleotidase 1 -2.79997
ACTR10 actin-related protein 10 homolog (S. cerevisiae) -2.44382
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.37766
APOO apolipoprotein O -2.37359
METTL9 methyltransferase like 9 -2.31173
BASP1 brain abundant, membrane attached signal protein 1 -2.25457
COA7 cytochrome c oxidase assembly factor 7 (putative) -2.21443
RBBP7 retinoblastoma binding protein 7 -2.20118
SLC13A4 solute carrier family 13 (sodium/sulfate symporter), member 4 -2.20042
B3GAT1 beta-1,3-glucuronyltransferase 1 -2.19568
CAPN2 calpain 2, (m/II) large subunit -2.17565
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.15873
ZNF248 zinc finger protein 248 -2.09188
CLCC1 chloride channel CLIC-like 1 -2.08404
LOC127933115 uncharacterized LOC127933115 -2.04145
TENT4A terminal nucleotidyltransferase 4A -2.03621
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria -2.031