CRCGN016_MCF10A.WT.HP_24H:F23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-methylaniline 33.54 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

66 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:F23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
C2CD2 C2 calcium-dependent domain containing 2 5.02517
SPAG4 sperm associated antigen 4 4.74866
FKBP14 FK506 binding protein 14, 22 kDa 4.72592
AGR2 anterior gradient 2 4.71302
ZNF586 zinc finger protein 586 4.08424
CREB1 cAMP responsive element binding protein 1 3.5557
ZNF134 zinc finger protein 134 3.49284
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.24166
WIF1 WNT inhibitory factor 1 3.22024
ZNF587 zinc finger protein 587 3.02562
ACAA1 acetyl-CoA acyltransferase 1 3.0142
VGLL4 vestigial-like family member 4 2.98811
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.86286
NCK2 NCK adaptor protein 2 2.76878
ZNF551 zinc finger protein 551 2.76127
ZNF587B zinc finger protein 587B 2.58548
MAP3K2 mitogen-activated protein kinase kinase kinase 2 2.53071
ZNF135 zinc finger protein 135 2.44703
ZIM3 zinc finger, imprinted 3 2.43778
FGD6 FYVE, RhoGEF and PH domain containing 6 2.39205
ZNF606 zinc finger protein 606 2.37705
H2BC21 H2B clustered histone 21 2.33613
LAMB1 laminin, beta 1 2.31257
AURKC aurora kinase C 2.30531
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 2.30515
ZNF304 zinc finger protein 304 2.24227
PTGFR prostaglandin F receptor (FP) 2.20921
TH tyrosine hydroxylase 2.19302
ZNF544 zinc finger protein 544 2.18688
C1QTNF3 C1q and tumor necrosis factor related protein 3 2.16099
ZNF419 zinc finger protein 419 2.14113
PHOX2B paired-like homeobox 2b 2.10428
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 2.10406
DDR1 discoidin domain receptor tyrosine kinase 1 2.10162
ZNF211 zinc finger protein 211 2.07182
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 2.0675
ZNF329 zinc finger protein 329 2.05308
BNC2 basonuclin 2 2.04414
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2.01997
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 2.01866
MAB21L4 mab-21 like 4 2.01324
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 2.00713

decreased expression

Symbol Name Standardized Value
UFM1 ubiquitin-fold modifier 1 -5.07371
HMG20B high mobility group 20B -4.78984
PCCB propionyl CoA carboxylase, beta polypeptide -4.7092
NUP85 nucleoporin 85kDa -4.69813
CAB39 calcium binding protein 39 -4.39543
SCYL3 SCY1-like 3 (S. cerevisiae) -4.04811
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.8692
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.6509
MRPS7 mitochondrial ribosomal protein S7 -2.81056
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.76693
LLGL2 lethal giant larvae homolog 2 (Drosophila) -2.67508
MRPL58 mitochondrial ribosomal protein L58 -2.65892
SGK1 serum/glucocorticoid regulated kinase 1 -2.62051
MT1X metallothionein 1X -2.53663
ATP5PD ATP synthase peripheral stalk subunit d -2.42148
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.37672
KLHDC4 kelch domain containing 4 -2.30163
BABAM1 BRISC and BRCA1 A complex member 1 -2.26724
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G -2.22342
MT1H metallothionein 1H -2.17688
GADD45B growth arrest and DNA-damage-inducible, beta -2.14198
BTBD1 BTB (POZ) domain containing 1 -2.06279
KLC3 kinesin light chain 3 -2.03112
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -2.02909