CRCGN016_MCF10A.WT.HP_24H:G07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,4'-methylene-bis(2-chloro?aniline) 97.94 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

156 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:G07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUCB2 nucleobindin 2 4.32828
TRIB3 tribbles pseudokinase 3 4.17324
GLRX glutaredoxin (thioltransferase) 3.55551
COMP cartilage oligomeric matrix protein 3.53646
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.38693
CHIC2 cysteine-rich hydrophobic domain 2 3.34159
LGMN legumain 3.3071
IDE insulin-degrading enzyme 3.29667
HMGA2 high mobility group AT-hook 2 3.17864
AGR2 anterior gradient 2 3.12806
LRP10 low density lipoprotein receptor-related protein 10 3.08446
S100A4 S100 calcium binding protein A4 3.05634
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.97479
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.91231
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 2.79657
TMEM59 transmembrane protein 59 2.73749
ETV4 ets variant 4 2.73654
TIAM1 T-cell lymphoma invasion and metastasis 1 2.66625
PRAF2 PRA1 domain family, member 2 2.61674
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.60693
MSRA methionine sulfoxide reductase A 2.59521
DHRS7 dehydrogenase/reductase (SDR family) member 7 2.57688
STK10 serine/threonine kinase 10 2.52658
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 2.46696
ATP10D ATPase, class V, type 10D 2.4263
LOC114841035 uncharacterized LOC114841035 2.41723
DUSP4 dual specificity phosphatase 4 2.41565
NIPSNAP1 nipsnap homolog 1 (C. elegans) 2.41417
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.41221
ECH1 enoyl CoA hydratase 1, peroxisomal 2.41128
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.35922
TRIB1 tribbles pseudokinase 1 2.358
FOXK2 forkhead box K2 2.34937
TXNDC15 thioredoxin domain containing 15 2.34464
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.34097
GAA glucosidase, alpha; acid 2.30954
MINPP1 multiple inositol-polyphosphate phosphatase 1 2.30737
RPN2 ribophorin II 2.29871
CRELD2 cysteine-rich with EGF-like domains 2 2.28519
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 2.24595
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.20902
GRN granulin 2.19667
MAPK6 mitogen-activated protein kinase 6 2.1802
P3H1 prolyl 3-hydroxylase 1 2.17641
SQLE squalene epoxidase 2.16642
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 2.1636
INSIG1 insulin induced gene 1 2.15779
VKORC1 vitamin K epoxide reductase complex, subunit 1 2.14775
WBP1L WW domain binding protein 1-like 2.14486
IER3 immediate early response 3 2.1026
SREBF1 sterol regulatory element binding transcription factor 1 2.07425
TCF12 transcription factor 12 2.06632
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.06142
IGFBP1 insulin-like growth factor binding protein 1 2.06082
ANO10 anoctamin 10 2.05567
GLB1 galactosidase, beta 1 2.04054
LAMC1 laminin, gamma 1 (formerly LAMB2) 2.01756
HEXB hexosaminidase B (beta polypeptide) 2.00731
ITGAV integrin, alpha V 2.00521
PLEK2 pleckstrin 2 2.00193
SLC35G2 solute carrier family 35, member G2 2.00128

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -6.76284
ADRB2 adrenoceptor beta 2, surface -4.41146
S100A8 S100 calcium binding protein A8 -4.38491
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -4.27642
SLC25A46 solute carrier family 25, member 46 -4.06823
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.91928
FAIM Fas apoptotic inhibitory molecule -3.82997
PRR15L proline rich 15-like -3.53119
PARP2 poly (ADP-ribose) polymerase 2 -3.43822
UBE2C ubiquitin-conjugating enzyme E2C -3.37759
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12) -3.34943
LDHD lactate dehydrogenase D -3.26733
CHMP4B charged multivesicular body protein 4B -3.17483
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.14802
NT5DC2 5'-nucleotidase domain containing 2 -2.92639
GCC1 GRIP and coiled-coil domain containing 1 -2.89986
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 -2.85633
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) -2.79583
HMGN3 high mobility group nucleosomal binding domain 3 -2.77873
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 -2.77189
C1QBP complement component 1, q subcomponent binding protein -2.70619
STMN1 stathmin 1 -2.70219
ANXA2 annexin A2 -2.67466
SGK1 serum/glucocorticoid regulated kinase 1 -2.67118
RINT1 RAD50 interactor 1 -2.59201
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.56228
PTK2 protein tyrosine kinase 2 -2.55845
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -2.50087
RBM34 RNA binding motif protein 34 -2.49927
MFSD12 major facilitator superfamily domain containing 12 -2.46809
GTPBP8 GTP-binding protein 8 (putative) -2.46569
SMNDC1 survival motor neuron domain containing 1 -2.46378
BET1 Bet1 golgi vesicular membrane trafficking protein -2.4599
TRIP6 thyroid hormone receptor interactor 6 -2.44005
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.42842
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein -2.42601
RALGDS ral guanine nucleotide dissociation stimulator -2.41541
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 -2.41429
SSBP1 single-stranded DNA binding protein 1, mitochondrial -2.40685
POT1 protection of telomeres 1 -2.40375
FASN fatty acid synthase -2.3926
NR2F1 nuclear receptor subfamily 2, group F, member 1 -2.37542
DUS4L dihydrouridine synthase 4-like (S. cerevisiae) -2.37203
NKAPD1 NKAP domain containing 1 -2.3689
ZNF134 zinc finger protein 134 -2.33472
ZNF35 zinc finger protein 35 -2.3255
DCK deoxycytidine kinase -2.31805
GINS2 GINS complex subunit 2 (Psf2 homolog) -2.31241
VTI1B vesicle transport through interaction with t-SNAREs 1B -2.3021
CTNND1 catenin (cadherin-associated protein), delta 1 -2.27911
PLK2 polo-like kinase 2 -2.23738
TLK2 tousled-like kinase 2 -2.23333
AUTS2 autism susceptibility candidate 2 -2.23323
POLR2J3 polymerase (RNA) II (DNA directed) polypeptide J3 -2.23217
GADD45B growth arrest and DNA-damage-inducible, beta -2.22697
DLAT dihydrolipoamide S-acetyltransferase -2.21352
SBNO1 strawberry notch homolog 1 (Drosophila) -2.21171
CDC20 cell division cycle 20 -2.21139
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 -2.20544
THAP1 THAP domain containing, apoptosis associated protein 1 -2.15905
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein -2.15154
KRT4 keratin 4, type II -2.14968
IMP4 IMP4, U3 small nucleolar ribonucleoprotein -2.14469
BAHCC1 BAH domain and coiled-coil containing 1 -2.14268
ZNF394 zinc finger protein 394 -2.13467
CERT1 ceramide transporter 1 -2.13128
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta -2.13015
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -2.11456
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae) -2.11173
RASA4B RAS p21 protein activator 4B -2.11138
ANKRD6 ankyrin repeat domain 6 -2.1029
PYY peptide YY -2.10023
RBM48 RNA binding motif protein 48 -2.09999
COMMD9 COMM domain containing 9 -2.09988
RPF1 ribosome production factor 1 homolog (S. cerevisiae) -2.09423
HRAS Harvey rat sarcoma viral oncogene homolog -2.09157
NR3C2 nuclear receptor subfamily 3, group C, member 2 -2.08083
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa -2.07676
ZNF14 zinc finger protein 14 -2.07363
RGS7 regulator of G-protein signaling 7 -2.05958
BECN1 beclin 1, autophagy related -2.05771
LOC128966597 MAL-like protein -2.05269
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial -2.04965
MYNN myoneurin -2.045
VDAC3 voltage-dependent anion channel 3 -2.04293
IPO4 importin 4 -2.04225
COG5 component of oligomeric golgi complex 5 -2.03597
MCM3 minichromosome maintenance complex component 3 -2.03582
COQ3 coenzyme Q3 methyltransferase -2.03158
PARP1 poly (ADP-ribose) polymerase 1 -2.02488
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) -2.01212
PARP8 poly (ADP-ribose) polymerase family, member 8 -2.01147
TRPM2 transient receptor potential cation channel, subfamily M, member 2 -2.00751
CAPN15 calpain 15 -2.0046
HOXA5 homeobox A5 -2.00061