CRCGN016_MCF10A.WT.HP_24H:G08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,4'-methylene-bis(2-chloro?aniline) 32.65 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

29 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:G08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DHRS2 dehydrogenase/reductase (SDR family) member 2 4.14314
AGR2 anterior gradient 2 3.9502
CXCL2 chemokine (C-X-C motif) ligand 2 3.84952
LGMN legumain 3.68481
PDLIM1 PDZ and LIM domain 1 3.39096
ADGRE5 adhesion G protein-coupled receptor E5 2.77131
PRKCH protein kinase C, eta 2.74003
S100A4 S100 calcium binding protein A4 2.58375
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.4996
HEBP1 heme binding protein 1 2.29588
INSIG1 insulin induced gene 1 2.28959
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.17457
CXCL3 chemokine (C-X-C motif) ligand 3 2.13316
RNMT RNA (guanine-7-) methyltransferase 2.08976
NUCB2 nucleobindin 2 2.01944

decreased expression

Symbol Name Standardized Value
CAB39 calcium binding protein 39 -3.88835
FASTKD5 FAST kinase domains 5 -3.88178
BASP1 brain abundant, membrane attached signal protein 1 -3.81413
LAP3 leucine aminopeptidase 3 -3.54763
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.45623
PCNA proliferating cell nuclear antigen -3.34574
KIF14 kinesin family member 14 -3.11234
KRT14 keratin 14, type I -2.44831
LYPLA1 lysophospholipase I -2.33598
PRR15L proline rich 15-like -2.28039
ADRB2 adrenoceptor beta 2, surface -2.16258
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) -2.10852
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.10179
AQP2 aquaporin 2 (collecting duct) -2.00077