CRCGN016_MCF10A.WT.HP_24H:G09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,4'-methylene-bis(2-chloro?aniline) 10.88 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

29 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:G09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 4.91106
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 3.92088
SPAG4 sperm associated antigen 4 3.66962
AGR2 anterior gradient 2 3.414
STAP2 signal transducing adaptor family member 2 3.32239
DENND2D DENN/MADD domain containing 2D 2.58448
WDR7 WD repeat domain 7 2.52559
C2CD2 C2 calcium-dependent domain containing 2 2.5079
CNPY3 canopy FGF signaling regulator 3 2.47922
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.37525
IGHMBP2 immunoglobulin mu binding protein 2 2.30716
RPN1 ribophorin I 2.27627
WFS1 Wolfram syndrome 1 (wolframin) 2.12188
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.08839
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 2.08568

decreased expression

Symbol Name Standardized Value
ACOT9 acyl-CoA thioesterase 9 -4.39674
PUF60 poly-U binding splicing factor 60KDa -3.55425
ENOPH1 enolase-phosphatase 1 -3.53668
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -3.43632
TM9SF3 transmembrane 9 superfamily member 3 -3.42011
CHMP4B charged multivesicular body protein 4B -3.16484
KIF20A kinesin family member 20A -2.88203
BASP1 brain abundant, membrane attached signal protein 1 -2.77642
TLCD3A TLC domain containing 3A -2.41162
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.31436
MICU1 mitochondrial calcium uptake 1 -2.20504
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.18488
TENT4A terminal nucleotidyltransferase 4A -2.09183
SERTAD3 SERTA domain containing 3 -2.04212