CRCGN016_MCF10A.WT.HP_24H:G11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description erythrosine 33.66 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

50 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:G11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.45288
AGR2 anterior gradient 2 4.36859
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 3.22494
OLFML2B olfactomedin-like 2B 2.86796
ALAS1 5'-aminolevulinate synthase 1 2.74401
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 2.64547
TRAPPC4 trafficking protein particle complex 4 2.49945
MOK MOK protein kinase 2.44685
CCDC92 coiled-coil domain containing 92 2.3722
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.37205
AARSD1 alanyl-tRNA synthetase domain containing 1 2.32425
FCHO1 FCH domain only 1 2.29656
COA3 cytochrome c oxidase assembly factor 3 2.29311
TXNL4B thioredoxin-like 4B 2.23708
LAGE3 L antigen family, member 3 2.23567
ICAM3 intercellular adhesion molecule 3 2.16882
PALS2 protein associated with LIN7 2, MAGUK p55 family member 2.03758

decreased expression

Symbol Name Standardized Value
ARID4B AT rich interactive domain 4B (RBP1-like) -5.10877
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.79867
KIF14 kinesin family member 14 -4.58473
SLC25A46 solute carrier family 25, member 46 -4.18829
UFM1 ubiquitin-fold modifier 1 -3.9354
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.92977
TXNDC9 thioredoxin domain containing 9 -3.89035
MSMO1 methylsterol monooxygenase 1 -3.85144
PRPF4 pre-mRNA processing factor 4 -3.76959
GDF15 growth differentiation factor 15 -3.60387
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -2.89281
PUF60 poly-U binding splicing factor 60KDa -2.76285
VDAC1 voltage-dependent anion channel 1 -2.55041
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -2.52746
MVD mevalonate (diphospho) decarboxylase -2.50633
GNAS GNAS complex locus -2.35724
SCRIB scribbled planar cell polarity protein -2.33911
CHRM3 cholinergic receptor, muscarinic 3 -2.30011
MTERF3 mitochondrial transcription termination factor 3 -2.26344
STRA6 stimulated by retinoic acid 6 -2.24639
MOCS3 molybdenum cofactor synthesis 3 -2.24293
DHCR7 7-dehydrocholesterol reductase -2.23807
SQLE squalene epoxidase -2.23081
RFC2 replication factor C (activator 1) 2, 40kDa -2.23018
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 -2.17606
CD58 CD58 molecule -2.14092
C4A complement component 4A (Rodgers blood group) -2.12076
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 -2.11419
RALGDS ral guanine nucleotide dissociation stimulator -2.08759
CORO2A coronin, actin binding protein, 2A -2.04907
LHB luteinizing hormone beta polypeptide -2.04496
MVK mevalonate kinase -2.01521
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.01366