CRCGN016_MCF10A.WT.HP_24H:G12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description erythrosine 11.22 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

59 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:G12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGR2 anterior gradient 2 4.60585
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.38342
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 4.1283
TBX2 T-box 2 4.10959
ZNF318 zinc finger protein 318 3.79889
CLNS1A chloride channel, nucleotide-sensitive, 1A 3.63519
UGDH UDP-glucose 6-dehydrogenase 3.5596
GATA2 GATA binding protein 2 3.32684
ACAA1 acetyl-CoA acyltransferase 1 3.3263
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.98453
SESN1 sestrin 1 2.91131
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.72859
HBA1 hemoglobin, alpha 1 2.69194
AAMDC adipogenesis associated, Mth938 domain containing 2.61387
BAX BCL2-associated X protein 2.51026
PKN1 protein kinase N1 2.36919
SRBD1 S1 RNA binding domain 1 2.29459
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 2.23641
VGLL4 vestigial-like family member 4 2.22676
RSF1 remodeling and spacing factor 1 2.11896
RAB7A RAB7A, member RAS oncogene family 2.10414
MGAM maltase-glucoamylase 2.06628

decreased expression

Symbol Name Standardized Value
GDF15 growth differentiation factor 15 -4.92995
TSPAN4 tetraspanin 4 -4.88841
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.80671
DNM1L dynamin 1-like -4.67205
SCYL3 SCY1-like 3 (S. cerevisiae) -4.55935
NPDC1 neural proliferation, differentiation and control, 1 -4.52149
HAT1 histone acetyltransferase 1 -4.50033
HMG20B high mobility group 20B -4.19853
TLCD3A TLC domain containing 3A -4.15914
NSDHL NAD(P) dependent steroid dehydrogenase-like -3.43368
MELK maternal embryonic leucine zipper kinase -3.31548
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -3.1108
ERGIC2 ERGIC and golgi 2 -3.1103
CSRP1 cysteine and glycine-rich protein 1 -2.96813
CANT1 calcium activated nucleotidase 1 -2.71493
DAAM1 dishevelled associated activator of morphogenesis 1 -2.63229
HTRA1 HtrA serine peptidase 1 -2.52054
CASQ2 calsequestrin 2 (cardiac muscle) -2.46881
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 -2.39916
SINHCAF SIN3-HDAC complex associated factor -2.37742
BCAP31 B-cell receptor-associated protein 31 -2.34461
EXT1 exostosin glycosyltransferase 1 -2.29766
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa -2.27547
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -2.26561
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 -2.25318
MTMR12 myotubularin related protein 12 -2.25151
INTS13 integrator complex subunit 13 -2.21763
E4F1 E4F transcription factor 1 -2.18672
UBN1 ubinuclein 1 -2.15191
RSAD2 radical S-adenosyl methionine domain containing 2 -2.12891
WAPL WAPL cohesin release factor -2.11701
ZNF500 zinc finger protein 500 -2.10038
MT1G metallothionein 1G -2.05602
CRIP2 cysteine-rich protein 2 -2.04465
MT1X metallothionein 1X -2.02928
AIM2 absent in melanoma 2 -2.02555
NXN nucleoredoxin -2.01053