CRCGN016_MCF10A.WT.HP_24H:G16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sirolimus 10.0 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

306 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:G16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SQSTM1 sequestosome 1 4.82269
KCTD5 potassium channel tetramerization domain containing 5 4.65792
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.60234
TXNRD1 thioredoxin reductase 1 4.5812
AGR2 anterior gradient 2 4.35156
CDCA4 cell division cycle associated 4 4.28775
HMGA2 high mobility group AT-hook 2 4.20794
FHL2 four and a half LIM domains 2 4.15407
RBKS ribokinase 3.99173
C2CD2 C2 calcium-dependent domain containing 2 3.85954
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.80355
CTSL cathepsin L 3.70273
SCCPDH saccharopine dehydrogenase (putative) 3.63857
GLRX glutaredoxin (thioltransferase) 3.47869
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 3.45227
FOSL1 FOS-like antigen 1 3.27071
SQOR sulfide quinone oxidoreductase 3.24902
ACAA1 acetyl-CoA acyltransferase 1 3.16972
LRP10 low density lipoprotein receptor-related protein 10 3.16861
STX1A syntaxin 1A (brain) 3.16005
PLEC plectin 3.05067
ITGB5 integrin, beta 5 3.03106
ABHD6 abhydrolase domain containing 6 3.02693
TMEM50A transmembrane protein 50A 2.99643
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 2.92032
NT5E 5'-nucleotidase, ecto (CD73) 2.76151
PYGL phosphorylase, glycogen, liver 2.75657
GRB10 growth factor receptor-bound protein 10 2.74782
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.68932
CERS2 ceramide synthase 2 2.64751
EGR1 early growth response 1 2.63695
TNIP1 TNFAIP3 interacting protein 1 2.61117
TLCD3A TLC domain containing 3A 2.6033
ACTMAP actin maturation protease 2.59252
SPAG1 sperm associated antigen 1 2.5904
NUCB2 nucleobindin 2 2.57345
PRAF2 PRA1 domain family, member 2 2.57323
PLA1A phospholipase A1 member A 2.53602
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 2.53538
SLC67A1 solute carrier family 67 member 1 2.52961
AKT1 v-akt murine thymoma viral oncogene homolog 1 2.51074
SPRY2 sprouty homolog 2 (Drosophila) 2.49161
FSCN1 fascin actin-bundling protein 1 2.44986
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 2.409
BAMBI BMP and activin membrane-bound inhibitor 2.39394
GPX4 glutathione peroxidase 4 2.37878
GADD45A growth arrest and DNA-damage-inducible, alpha 2.36123
TLR4 toll-like receptor 4 2.36015
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.32175
POPDC3 popeye domain containing 3 2.31815
CDK5RAP3 CDK5 regulatory subunit associated protein 3 2.31556
ERCC2 excision repair cross-complementation group 2 2.31158
SDC4 syndecan 4 2.30227
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.27101
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.26997
GAA glucosidase, alpha; acid 2.26148
SH3BP4 SH3-domain binding protein 4 2.25355
PARN poly(A)-specific ribonuclease 2.25007
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.24973
HBA1 hemoglobin, alpha 1 2.24411
PHKB phosphorylase kinase, beta 2.24326
CCDC92 coiled-coil domain containing 92 2.24142
DKK1 dickkopf WNT signaling pathway inhibitor 1 2.24128
CXCL2 chemokine (C-X-C motif) ligand 2 2.23839
TM9SF3 transmembrane 9 superfamily member 3 2.23677
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.23349
PAQR4 progestin and adipoQ receptor family member IV 2.22318
COMP cartilage oligomeric matrix protein 2.21762
CHMP4B charged multivesicular body protein 4B 2.21478
DAD1 defender against cell death 1 2.21133
LMF2 lipase maturation factor 2 2.20489
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B 2.19575
RABAC1 Rab acceptor 1 (prenylated) 2.19059
VEGFC vascular endothelial growth factor C 2.18119
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 2.17033
BCOR BCL6 corepressor 2.16357
ARID5B AT rich interactive domain 5B (MRF1-like) 2.15697
SLF2 SMC5-SMC6 complex localization factor 2 2.15152
TRAF3 TNF receptor-associated factor 3 2.15106
RNF220 ring finger protein 220 2.14164
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 2.13603
ZC3H14 zinc finger CCCH-type containing 14 2.12796
MSRA methionine sulfoxide reductase A 2.12295
GOLGA3 golgin A3 2.12109
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 2.11106
TFF3 trefoil factor 3 (intestinal) 2.10534
KLRC1 killer cell lectin-like receptor subfamily C, member 1 2.08728
DUSP4 dual specificity phosphatase 4 2.08043
AATF apoptosis antagonizing transcription factor 2.07792
HPR haptoglobin-related protein 2.07694
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 2.074
HEXB hexosaminidase B (beta polypeptide) 2.06843
IRS1 insulin receptor substrate 1 2.06807
PRMT3 protein arginine methyltransferase 3 2.0612
SOX9 SRY (sex determining region Y)-box 9 2.0604
IL32 interleukin 32 2.05246
HDAC4 histone deacetylase 4 2.05157
FAM50A family with sequence similarity 50, member A 2.02508
SYNE2 spectrin repeat containing, nuclear envelope 2 2.02366
DLK1 delta-like 1 homolog (Drosophila) 2.02331
DNMBP dynamin binding protein 2.00226

decreased expression

Symbol Name Standardized Value
S100A8 S100 calcium binding protein A8 -8.71847
PRR15L proline rich 15-like -4.88063
ALDOC aldolase C, fructose-bisphosphate -4.87421
CLDN7 claudin 7 -4.27573
LDHD lactate dehydrogenase D -4.2164
DDIT4 DNA-damage-inducible transcript 4 -4.10334
YME1L1 YME1-like 1 ATPase -3.95922
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.86468
RNF139 ring finger protein 139 -3.82062
INSIG1 insulin induced gene 1 -3.81058
MSMO1 methylsterol monooxygenase 1 -3.5327
HSPB1 heat shock 27kDa protein 1 -3.46187
DNM1L dynamin 1-like -3.46123
FASTKD5 FAST kinase domains 5 -3.41712
TSC22D3 TSC22 domain family, member 3 -3.36179
HCFC2 host cell factor C2 -3.34558
NLRP2B NLR family pyrin domain containing 2B -3.26634
CDPF1 cysteine-rich, DPF motif domain containing 1 -3.23798
COPS4 COP9 signalosome subunit 4 -3.19251
SMNDC1 survival motor neuron domain containing 1 -3.19107
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -3.16964
PSRC1 proline/serine-rich coiled-coil 1 -3.14469
PRPF18 pre-mRNA processing factor 18 -3.12635
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -3.12615
TUBA1C tubulin, alpha 1c -3.07825
ATP5PO ATP synthase peripheral stalk subunit OSCP -3.05671
ATP5PB ATP synthase peripheral stalk-membrane subunit b -3.0541
S100A4 S100 calcium binding protein A4 -3.04399
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 -2.98705
USP2 ubiquitin specific peptidase 2 -2.98134
OXR1 oxidation resistance 1 -2.96688
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 -2.96497
TUBA1B tubulin, alpha 1b -2.95624
GTPBP8 GTP-binding protein 8 (putative) -2.9382
PCCB propionyl CoA carboxylase, beta polypeptide -2.89453
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 -2.82849
MKKS McKusick-Kaufman syndrome -2.82505
RNF167 ring finger protein 167 -2.81343
MRPL39 mitochondrial ribosomal protein L39 -2.80986
NOTCH1 notch 1 -2.77866
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.74418
IFT46 intraflagellar transport 46 -2.73875
LBR lamin B receptor -2.65716
TRPM2 transient receptor potential cation channel, subfamily M, member 2 -2.65575
ZNF322 zinc finger protein 322 -2.65546
EHF ets homologous factor -2.64985
TCEA2 transcription elongation factor A (SII), 2 -2.64683
ATP5PF ATP synthase peripheral stalk subunit F6 -2.6246
MFN1 mitofusin 1 -2.6199
ZNF394 zinc finger protein 394 -2.60668
USP8 ubiquitin specific peptidase 8 -2.60203
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.60024
MED21 mediator complex subunit 21 -2.59852
GNAS GNAS complex locus -2.59319
SH3D19 SH3 domain containing 19 -2.58888
DCK deoxycytidine kinase -2.5726
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A -2.57229
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.54146
LEMD3 LEM domain containing 3 -2.53108
SESN1 sestrin 1 -2.52515
MTPAP mitochondrial poly(A) polymerase -2.51969
GADD45B growth arrest and DNA-damage-inducible, beta -2.51664
CYCS cytochrome c, somatic -2.50945
ATP5F1C ATP synthase F1 subunit gamma -2.50856
ZNF134 zinc finger protein 134 -2.50608
HAUS3 HAUS augmin-like complex, subunit 3 -2.50595
CALM2 calmodulin 2 (phosphorylase kinase, delta) -2.48749
TUBA1A tubulin, alpha 1a -2.47388
CDH18 cadherin 18, type 2 -2.46948
KRT15 keratin 15, type I -2.46129
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.4491
RGPD2 RANBP2-like and GRIP domain containing 2 -2.44812
BCAS2 breast carcinoma amplified sequence 2 -2.44619
ATF3 activating transcription factor 3 -2.44423
MEIS2 Meis homeobox 2 -2.43828
HEXIM1 hexamethylene bis-acetamide inducible 1 -2.4378
MNAT1 MNAT CDK-activating kinase assembly factor 1 -2.42583
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -2.42485
HIRA histone cell cycle regulator -2.4226
PLPPR4 phospholipid phosphatase related 4 -2.42088
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.41657
MTMR12 myotubularin related protein 12 -2.41527
MORC3 MORC family CW-type zinc finger 3 -2.41187
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 -2.41072
ADGRB3 adhesion G protein-coupled receptor B3 -2.4076
CROT carnitine O-octanoyltransferase -2.388
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.38539
CHODL chondrolectin -2.38329
GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 -2.37493
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 -2.37238
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -2.36447
GTF2A2 general transcription factor IIA, 2, 12kDa -2.35759
AP5M1 adaptor-related protein complex 5, mu 1 subunit -2.35278
TSPAN12 tetraspanin 12 -2.35206
PREPL prolyl endopeptidase-like -2.35141
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae) -2.34736
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.34152
POLR3B polymerase (RNA) III (DNA directed) polypeptide B -2.33733
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria -2.33687
MIS12 MIS12 kinetochore complex component -2.32484
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -2.30894
BIRC5 baculoviral IAP repeat containing 5 -2.30648
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma -2.3063
AP1B1 adaptor-related protein complex 1, beta 1 subunit -2.30262
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein -2.29659
KRT14 keratin 14, type I -2.29208
ZSCAN16 zinc finger and SCAN domain containing 16 -2.2919
UBE2E1 ubiquitin-conjugating enzyme E2E 1 -2.28382
TYW2 tRNA wybutosine-synthesizing protein 2 -2.27993
CISD1 CDGSH iron sulfur domain 1 -2.27952
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 -2.27601
KRABD4 KRAB domain containing 4 -2.27367
MDH1 malate dehydrogenase 1, NAD (soluble) -2.26894
LAMB1 laminin, beta 1 -2.26787
KRT13 keratin 13, type I -2.25635
EGFL6 EGF-like-domain, multiple 6 -2.25554
RHOT1 ras homolog family member T1 -2.25533
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -2.25379
SGK1 serum/glucocorticoid regulated kinase 1 -2.25346
MREG melanoregulin -2.24323
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38 -2.24156
SREBF1 sterol regulatory element binding transcription factor 1 -2.23851
RNASE7 ribonuclease, RNase A family, 7 -2.23371
ST14 suppression of tumorigenicity 14 (colon carcinoma) -2.23258
RABL6 RAB, member RAS oncogene family-like 6 -2.23001
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 -2.22755
CTSK cathepsin K -2.22356
CDC40 cell division cycle 40 -2.22333
PNRC2 proline-rich nuclear receptor coactivator 2 -2.22019
CD58 CD58 molecule -2.21913
ARMC7 armadillo repeat containing 7 -2.21788
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.21722
RNF111 ring finger protein 111 -2.20212
SRFBP1 serum response factor binding protein 1 -2.20036
CSTA cystatin A (stefin A) -2.19989
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 -2.19614
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa -2.17932
ARMCX1 armadillo repeat containing, X-linked 1 -2.17868
CGRRF1 cell growth regulator with ring finger domain 1 -2.17367
RGS5 regulator of G-protein signaling 5 -2.16864
PRELID3B PRELI domain containing 3B -2.16482
ARRB1 arrestin, beta 1 -2.16032
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 -2.15813
CAND1 cullin-associated and neddylation-dissociated 1 -2.15307
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 -2.14664
DNM1 dynamin 1 -2.14248
HSPA14 heat shock 70kDa protein 14 -2.14077
FAM13A family with sequence similarity 13, member A -2.13866
ZC3H15 zinc finger CCCH-type containing 15 -2.13668
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -2.13649
USP19 ubiquitin specific peptidase 19 -2.13601
NME5 NME/NM23 family member 5 -2.13597
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains -2.13574
CKMT1A creatine kinase, mitochondrial 1A -2.13391
ADGRL3 adhesion G protein-coupled receptor L3 -2.13245
MTNAP1 mitochondrial nucleoid associated protein 1 -2.13179
ABI3BP ABI family, member 3 (NESH) binding protein -2.12722
PCDHB3 protocadherin beta 3 -2.12186
GRB2 growth factor receptor-bound protein 2 -2.11463
WASL Wiskott-Aldrich syndrome-like -2.1143
REG1B regenerating islet-derived 1 beta -2.11338
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -2.11276
LZTS3 leucine zipper, putative tumor suppressor family member 3 -2.11248
METTL4 methyltransferase like 4 -2.10925
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -2.10488
SPTBN2 spectrin, beta, non-erythrocytic 2 -2.10036
CEP70 centrosomal protein 70kDa -2.10017
CLDN4 claudin 4 -2.08304
MOCS2 molybdenum cofactor synthesis 2 -2.08246
NDUFAF1 NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 -2.07891
LOC124906748 beta-defensin 4A -2.07876
NPEPPS aminopeptidase puromycin sensitive -2.07767
CBR3 carbonyl reductase 3 -2.07519
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5 -2.0739
KLHDC3 kelch domain containing 3 -2.06968
ACTR6 ARP6 actin-related protein 6 homolog (yeast) -2.06956
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2 -2.06907
NRBP1 nuclear receptor binding protein 1 -2.06651
SCNN1B sodium channel, non voltage gated 1 beta subunit -2.0608
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 -2.05963
TREM2 triggering receptor expressed on myeloid cells 2 -2.05896
MCAM melanoma cell adhesion molecule -2.05454
OXSR1 oxidative stress responsive 1 -2.05041
SRSF3 serine/arginine-rich splicing factor 3 -2.04869
CCT8 chaperonin containing TCP1, subunit 8 (theta) -2.04844
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 -2.03926
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) -2.03386
RERGL RERG/RAS-like -2.0305
PARD6A par-6 family cell polarity regulator alpha -2.02648
HIGD1B HIG1 hypoxia inducible domain family, member 1B -2.0241
REPIN1 replication initiator 1 -2.02406
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 -2.02348
LPAR3 lysophosphatidic acid receptor 3 -2.02179
ATG4A autophagy related 4A, cysteine peptidase -2.02178
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -2.01957
ZNF415 zinc finger protein 415 -2.01927
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) -2.01728
NDRG3 NDRG family member 3 -2.01662
ZNF207 zinc finger protein 207 -2.01359
SYNJ1 synaptojanin 1 -2.01067
GTF2B general transcription factor IIB -2.00948
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.00897
NRTN neurturin -2.00518
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta -2.00191
RPL39 ribosomal protein L39 -2.00137