CRCGN016_MCF10A.WT.HP_24H:G17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sirolimus 3.33 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

139 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:G17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 5.30893
HMGA2 high mobility group AT-hook 2 4.28686
SCCPDH saccharopine dehydrogenase (putative) 3.99516
MAMLD1 mastermind-like domain containing 1 3.73936
EVL Enah/Vasp-like 3.68712
MAP7 microtubule-associated protein 7 3.66952
TATDN2 TatD DNase domain containing 2 3.50495
IGFBP3 insulin-like growth factor binding protein 3 3.37682
CXCL3 chemokine (C-X-C motif) ligand 3 3.34552
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 3.19772
MYC v-myc avian myelocytomatosis viral oncogene homolog 3.16007
NPDC1 neural proliferation, differentiation and control, 1 3.13129
AGR2 anterior gradient 2 3.07385
FHL2 four and a half LIM domains 2 2.95618
MCUR1 mitochondrial calcium uniporter regulator 1 2.92074
PDIA5 protein disulfide isomerase family A, member 5 2.90639
MEAF6 MYST/Esa1-associated factor 6 2.81003
NT5E 5'-nucleotidase, ecto (CD73) 2.80381
TSPAN4 tetraspanin 4 2.71149
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.62231
TMEM50A transmembrane protein 50A 2.59174
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.56414
TLCD3A TLC domain containing 3A 2.54305
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.48353
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) 2.48345
RBKS ribokinase 2.42897
PYGL phosphorylase, glycogen, liver 2.41412
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.39612
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.39303
IGHMBP2 immunoglobulin mu binding protein 2 2.34326
XDH xanthine dehydrogenase 2.28533
LPO lactoperoxidase 2.24292
SMYD5 SMYD family member 5 2.23682
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.23122
FMNL3 formin-like 3 2.22035
CIAO3 cytosolic iron-sulfur assembly component 3 2.21136
PRL prolactin 2.20107
CKAP4 cytoskeleton-associated protein 4 2.19785
BTN1A1 butyrophilin, subfamily 1, member A1 2.17669
CETN2 centrin, EF-hand protein, 2 2.17141
TXNRD3 thioredoxin reductase 3 2.15174
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 2.13948
CHD9NB CHD9 neighbor 2.13743
OXCT1 3-oxoacid CoA transferase 1 2.10948
CZIB CXXC motif containing zinc binding protein 2.08746
NT5DC3 5'-nucleotidase domain containing 3 2.08347
TBC1D5 TBC1 domain family, member 5 2.07485
AGO2 argonaute RISC catalytic component 2 2.07138
EGFR epidermal growth factor receptor 2.05392
SPA17 sperm autoantigenic protein 17 2.04932
BPI bactericidal/permeability-increasing protein 2.04869
CHN1 chimerin 1 2.04386
NUP210 nucleoporin 210kDa 2.0422
CRELD2 cysteine-rich with EGF-like domains 2 2.02723
ITGB5 integrin, beta 5 2.02614
FOSL1 FOS-like antigen 1 2.01747
TCTN1 tectonic family member 1 2.01258
CBY1 chibby homolog 1 (Drosophila) 2.01093
TMEM43 transmembrane protein 43 2.00199
RAB3D RAB3D, member RAS oncogene family 2.00052

decreased expression

Symbol Name Standardized Value
S100A8 S100 calcium binding protein A8 -6.76881
GDF15 growth differentiation factor 15 -5.16177
KRT14 keratin 14, type I -4.95344
SGK1 serum/glucocorticoid regulated kinase 1 -4.2181
MSMO1 methylsterol monooxygenase 1 -4.20348
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.0794
SLC25A46 solute carrier family 25, member 46 -3.92757
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.91996
PRR15L proline rich 15-like -3.68545
RNF167 ring finger protein 167 -3.65163
GOLT1B golgi transport 1B -3.56625
CD58 CD58 molecule -3.53432
DDIT4 DNA-damage-inducible transcript 4 -3.52484
TUBA4A tubulin, alpha 4a -3.50388
CDPF1 cysteine-rich, DPF motif domain containing 1 -3.17069
HSPB1 heat shock 27kDa protein 1 -3.07209
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.00208
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.98531
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.95147
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.85566
INSIG1 insulin induced gene 1 -2.79682
S100A4 S100 calcium binding protein A4 -2.69497
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.66759
PFN1 profilin 1 -2.65582
VDAC1 voltage-dependent anion channel 1 -2.64634
CTNND1 catenin (cadherin-associated protein), delta 1 -2.56615
ABHD4 abhydrolase domain containing 4 -2.54345
ATF5 activating transcription factor 5 -2.54297
RNASE7 ribonuclease, RNase A family, 7 -2.53869
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -2.53615
GTPBP8 GTP-binding protein 8 (putative) -2.53225
MAGEH1 melanoma antigen family H1 -2.52261
WDR26 WD repeat domain 26 -2.48009
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.46519
EMC7 ER membrane protein complex subunit 7 -2.453
MRPL49 mitochondrial ribosomal protein L49 -2.37036
SEC24C SEC24 family member C -2.36691
GGPS1 geranylgeranyl diphosphate synthase 1 -2.36528
RNF139 ring finger protein 139 -2.29768
CCDC69 coiled-coil domain containing 69 -2.29685
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -2.28021
ALDOC aldolase C, fructose-bisphosphate -2.27715
TRIB3 tribbles pseudokinase 3 -2.26125
TMX2 thioredoxin-related transmembrane protein 2 -2.25724
SHOC2 soc-2 suppressor of clear homolog (C. elegans) -2.24906
SH3D19 SH3 domain containing 19 -2.23799
LBR lamin B receptor -2.22331
RETREG3 reticulophagy regulator family member 3 -2.22165
ZNF432 zinc finger protein 432 -2.21761
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.21443
SEPHS2 selenophosphate synthetase 2 -2.19005
RCOR3 REST corepressor 3 -2.18823
GPR20 G protein-coupled receptor 20 -2.18112
STXBP2 syntaxin binding protein 2 -2.17963
MINDY1 MINDY lysine 48 deubiquitinase 1 -2.17122
SLC25A44 solute carrier family 25, member 44 -2.16981
CHD8 chromodomain helicase DNA binding protein 8 -2.16383
QPRT quinolinate phosphoribosyltransferase -2.15926
RHCG Rh family, C glycoprotein -2.15565
OSTM1 osteopetrosis associated transmembrane protein 1 -2.14798
TBCE tubulin folding cofactor E -2.12006
CD81 CD81 molecule -2.11643
SLC39A7 solute carrier family 39 (zinc transporter), member 7 -2.11504
ADGRE5 adhesion G protein-coupled receptor E5 -2.10921
PCDH17 protocadherin 17 -2.10729
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 -2.09061
USP8 ubiquitin specific peptidase 8 -2.08743
OXR1 oxidation resistance 1 -2.08548
IFI30 interferon, gamma-inducible protein 30 -2.08054
PRR13 proline rich 13 -2.07859
H2AC19 H2A clustered histone 19 -2.06234
NKAPD1 NKAP domain containing 1 -2.05518
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 -2.0522
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A -2.04886
NELL1 NEL-like 1 (chicken) -2.04625
ARID4B AT rich interactive domain 4B (RBP1-like) -2.04421
BFAR bifunctional apoptosis regulator -2.03476
MT1X metallothionein 1X -2.03222
TMEM184C transmembrane protein 184C -2.02194