CRCGN016_MCF10A.WT.HP_24H:G18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sirolimus 1.11 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

121 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:G18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.12836
MAMLD1 mastermind-like domain containing 1 3.97133
MTA2 metastasis associated 1 family, member 2 3.75731
HMGA2 high mobility group AT-hook 2 3.71436
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.6805
BID BH3 interacting domain death agonist 3.67491
COMP cartilage oligomeric matrix protein 3.08156
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 3.05154
FHL2 four and a half LIM domains 2 3.02932
MYC v-myc avian myelocytomatosis viral oncogene homolog 3.00172
SCCPDH saccharopine dehydrogenase (putative) 2.77601
NT5E 5'-nucleotidase, ecto (CD73) 2.73367
IGHMBP2 immunoglobulin mu binding protein 2 2.72184
ITGB5 integrin, beta 5 2.68888
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 2.67292
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.59858
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2.41896
PDIA5 protein disulfide isomerase family A, member 5 2.39377
TSPAN4 tetraspanin 4 2.37687
MICALL1 MICAL-like 1 2.36638
TMEM50A transmembrane protein 50A 2.36132
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.32838
THRAP3 thyroid hormone receptor associated protein 3 2.31111
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 2.28241
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.27446
STAT2 signal transducer and activator of transcription 2, 113kDa 2.27068
CLDN1 claudin 1 2.21006
HNRNPL heterogeneous nuclear ribonucleoprotein L 2.19284
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 2.1785
DENND4B DENN/MADD domain containing 4B 2.15204
CCNA1 cyclin A1 2.15008
ZNF783 zinc finger family member 783 2.14952
STRN3 striatin, calmodulin binding protein 3 2.13729
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 2.12748
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 2.12071
TNIP1 TNFAIP3 interacting protein 1 2.1195
TM9SF1 transmembrane 9 superfamily member 1 2.11076
GMEB1 glucocorticoid modulatory element binding protein 1 2.11041
TP53 tumor protein p53 2.10718
FAM3C family with sequence similarity 3, member C 2.10708
PYGL phosphorylase, glycogen, liver 2.10029
TPM1 tropomyosin 1 (alpha) 2.0921
FNDC3B fibronectin type III domain containing 3B 2.09166
CDCA4 cell division cycle associated 4 2.08201
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.07089
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 2.06445
EGFR epidermal growth factor receptor 2.06108
XDH xanthine dehydrogenase 2.05777
CHRND cholinergic receptor, nicotinic, delta (muscle) 2.05691
DUSP13A dual specificity phosphatase 13A 2.05425
DKK1 dickkopf WNT signaling pathway inhibitor 1 2.05177
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 2.04988
STX1A syntaxin 1A (brain) 2.03331
AMHR2 anti-Mullerian hormone receptor, type II 2.02461
ADSL adenylosuccinate lyase 2.02168
SGSH N-sulfoglucosamine sulfohydrolase 2.02059
ACAA1 acetyl-CoA acyltransferase 1 2.01604
LMF2 lipase maturation factor 2 2.00048

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -6.18017
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -5.10939
ALDOC aldolase C, fructose-bisphosphate -4.62489
ADI1 acireductone dioxygenase 1 -4.52929
CD58 CD58 molecule -4.18226
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -4.00995
GDF15 growth differentiation factor 15 -3.89242
SLC35F2 solute carrier family 35, member F2 -3.56426
TRAPPC3 trafficking protein particle complex 3 -3.38962
DDIT4 DNA-damage-inducible transcript 4 -3.37793
PRR15L proline rich 15-like -3.29518
KRT14 keratin 14, type I -3.27452
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.24137
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -3.23015
HSPB1 heat shock 27kDa protein 1 -2.95915
RPIA ribose 5-phosphate isomerase A -2.94842
ARID4B AT rich interactive domain 4B (RBP1-like) -2.93358
CDPF1 cysteine-rich, DPF motif domain containing 1 -2.9011
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.88582
S100A4 S100 calcium binding protein A4 -2.88031
INSIG1 insulin induced gene 1 -2.67608
PCCB propionyl CoA carboxylase, beta polypeptide -2.67476
STAP2 signal transducing adaptor family member 2 -2.64224
CAMKMT calmodulin-lysine N-methyltransferase -2.62584
RNASE7 ribonuclease, RNase A family, 7 -2.59777
FBXO3 F-box protein 3 -2.54853
CGRRF1 cell growth regulator with ring finger domain 1 -2.53618
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 -2.45447
TBCE tubulin folding cofactor E -2.45179
BBS4 Bardet-Biedl syndrome 4 -2.40784
MRPL34 mitochondrial ribosomal protein L34 -2.32398
SESN1 sestrin 1 -2.32327
RETREG3 reticulophagy regulator family member 3 -2.32138
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) -2.31985
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.30371
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 -2.30245
LBR lamin B receptor -2.29669
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 -2.29174
SMAP1 small ArfGAP 1 -2.28294
ABHD4 abhydrolase domain containing 4 -2.28278
BABAM1 BRISC and BRCA1 A complex member 1 -2.27936
TOB1 transducer of ERBB2, 1 -2.26666
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.24616
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 -2.21929
RBM34 RNA binding motif protein 34 -2.21912
ECSIT ECSIT signalling integrator -2.17781
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -2.16327
MRPS15 mitochondrial ribosomal protein S15 -2.14611
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 -2.14275
NAP1L2 nucleosome assembly protein 1-like 2 -2.12825
CCDC59 coiled-coil domain containing 59 -2.11426
BPGM 2,3-bisphosphoglycerate mutase -2.10987
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein -2.10553
TUBD1 tubulin, delta 1 -2.09295
MNAT1 MNAT CDK-activating kinase assembly factor 1 -2.08373
POU2AF1 POU class 2 associating factor 1 -2.08259
NLRP2B NLR family pyrin domain containing 2B -2.07907
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.07736
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa -2.0581
BLTP3B bridge-like lipid transfer protein family member 3B -2.05492
NELL1 NEL-like 1 (chicken) -2.05107
H1-2 H1.2 linker histone, cluster member -2.03494
SLC2A14 solute carrier family 2 (facilitated glucose transporter), member 14 -2.02977