CRCGN016_MCF10A.WT.HP_24H:G20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-amino-5-nitrothiazole 32.1 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

51 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:G20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HMOX1 heme oxygenase 1 5.46821
APOE apolipoprotein E 5.16635
TSEN2 TSEN2 tRNA splicing endonuclease subunit 5.14854
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 4.88123
FAM20B family with sequence similarity 20, member B 4.13687
AGR2 anterior gradient 2 3.98438
STK10 serine/threonine kinase 10 2.88104
GOLGA6L9 golgin A6 family-like 9 2.62804
WIF1 WNT inhibitory factor 1 2.32395
GET1 guided entry of tail-anchored proteins factor 1 2.24166
APOC1 apolipoprotein C-I 2.19241
RIC8B RIC8 guanine nucleotide exchange factor B 2.18511
TOR1AIP2 torsin A interacting protein 2 2.17104
FPGS folylpolyglutamate synthase 2.0252
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 2.02038

decreased expression

Symbol Name Standardized Value
CRK v-crk avian sarcoma virus CT10 oncogene homolog -4.82126
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -4.7877
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.35059
BASP1 brain abundant, membrane attached signal protein 1 -3.57397
COG2 component of oligomeric golgi complex 2 -3.23103
SGK1 serum/glucocorticoid regulated kinase 1 -3.1179
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.84933
TMEM115 transmembrane protein 115 -2.60801
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.537
IFRD2 interferon-related developmental regulator 2 -2.49608
ZNF747 zinc finger protein 747 -2.47709
KDM5C lysine (K)-specific demethylase 5C -2.46242
NOP14 NOP14 nucleolar protein -2.44111
TENT4A terminal nucleotidyltransferase 4A -2.40586
ZNF528 zinc finger protein 528 -2.38296
HSF1 heat shock transcription factor 1 -2.3568
EIF3I eukaryotic translation initiation factor 3, subunit I -2.34655
TTLL12 tubulin tyrosine ligase-like family member 12 -2.24212
PITPNA phosphatidylinositol transfer protein, alpha -2.22329
ACAA1 acetyl-CoA acyltransferase 1 -2.20307
JMJD4 jumonji domain containing 4 -2.19996
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) -2.19633
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 -2.15623
TWNK twinkle mtDNA helicase -2.1467
GTPBP3 GTP binding protein 3 (mitochondrial) -2.12565
CARM1 coactivator-associated arginine methyltransferase 1 -2.12351
PRSS58 protease, serine, 58 -2.09708
CNN2 calponin 2 -2.08538
IP6K1 inositol hexakisphosphate kinase 1 -2.08409
DNASE1L2 deoxyribonuclease I-like 2 -2.08366
CPTP ceramide-1-phosphate transfer protein -2.08056
BPHL biphenyl hydrolase-like (serine hydrolase) -2.07553
ZHX2 zinc fingers and homeoboxes 2 -2.05707
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa -2.02984
MYBBP1A MYB binding protein (P160) 1a -2.026
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.02444