CRCGN016_MCF10A.WT.HP_24H:G21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-amino-5-nitrothiazole 10.7 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

20 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:G21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCL2 chemokine (C-C motif) ligand 2 6.46953
HMOX1 heme oxygenase 1 5.40751
TBPL1 TBP-like 1 4.84152
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.64391
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.99869
EVL Enah/Vasp-like 2.91063
TCEAL4 transcription elongation factor A (SII)-like 4 2.53007
ACAA1 acetyl-CoA acyltransferase 1 2.20694
IL32 interleukin 32 2.1694
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.14043

decreased expression

Symbol Name Standardized Value
CHMP4B charged multivesicular body protein 4B -5.45386
RPA3 replication protein A3, 14kDa -4.23154
MAPK13 mitogen-activated protein kinase 13 -3.82552
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 -3.68321
FOS FBJ murine osteosarcoma viral oncogene homolog -3.52598
ATF5 activating transcription factor 5 -3.27044
TIMP1 TIMP metallopeptidase inhibitor 1 -3.21847
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.60885
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -2.50864
GDF15 growth differentiation factor 15 -2.18286