CRCGN016_MCF10A.WT.HP_24H:G23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,6-dimethylaniline 32.74 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

79 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:G23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
C2CD2 C2 calcium-dependent domain containing 2 8.19848
KIF5C kinesin family member 5C 4.43452
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 4.15953
GPER1 G protein-coupled estrogen receptor 1 3.49312
DHDDS dehydrodolichyl diphosphate synthase 3.3581
TSPYL5 TSPY-like 5 2.70664
CNPY3 canopy FGF signaling regulator 3 2.69972
CAPN1 calpain 1, (mu/I) large subunit 2.59366
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) 2.53745
LEP leptin 2.53289
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G 2.50352
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 2.43629
KLHDC8A kelch domain containing 8A 2.42581
NYNRIN NYN domain and retroviral integrase containing 2.40371
LAIR2 leukocyte-associated immunoglobulin-like receptor 2 2.3755
STMN2 stathmin 2 2.35033
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.33674
SFTPD surfactant protein D 2.27098
AGR2 anterior gradient 2 2.21921
MAP3K10 mitogen-activated protein kinase kinase kinase 10 2.2154
MELK maternal embryonic leucine zipper kinase 2.20654
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 2.18859
TIMP2 TIMP metallopeptidase inhibitor 2 2.17293
E2F2 E2F transcription factor 2 2.16742
SH3TC1 SH3 domain and tetratricopeptide repeats 1 2.16473
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 2.15287
ONECUT2 one cut homeobox 2 2.14476
FXYD3 FXYD domain containing ion transport regulator 3 2.14285
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) 2.13686
CCDC57 coiled-coil domain containing 57 2.13186
TBX19 T-box 19 2.11717
TCHH trichohyalin 2.11433
PIGO phosphatidylinositol glycan anchor biosynthesis, class O 2.11269
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 2.11171
KLK15 kallikrein-related peptidase 15 2.10134
CCDC85C coiled-coil domain containing 85C 2.09772
CCN5 cellular communication network factor 5 2.08116
TLCD3A TLC domain containing 3A 2.0695
EHMT1 euchromatic histone-lysine N-methyltransferase 1 2.0594
NAT10 N-acetyltransferase 10 (GCN5-related) 2.05367
BARX2 BARX homeobox 2 2.05032
ACAA1 acetyl-CoA acyltransferase 1 2.04952
CNPPD1 cyclin Pas1/PHO80 domain containing 1 2.03642
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2 2.03583
LIPE lipase, hormone-sensitive 2.02434
CADM1 cell adhesion molecule 1 2.0236
TARBP1 TAR (HIV-1) RNA binding protein 1 2.02169
TSPAN14 tetraspanin 14 2.01708
IFNB1 interferon, beta 1, fibroblast 2.00983

decreased expression

Symbol Name Standardized Value
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -5.91123
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -5.51751
PCNA proliferating cell nuclear antigen -5.36417
HMG20B high mobility group 20B -4.58439
PUF60 poly-U binding splicing factor 60KDa -3.76961
CANT1 calcium activated nucleotidase 1 -3.41719
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.2902
S100A8 S100 calcium binding protein A8 -3.16744
RHOT2 ras homolog family member T2 -2.73666
ACOT9 acyl-CoA thioesterase 9 -2.719
VDAC1 voltage-dependent anion channel 1 -2.60291
CRNKL1 crooked neck pre-mRNA splicing factor 1 -2.57753
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.56346
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) -2.47531
MRPL30 mitochondrial ribosomal protein L30 -2.43735
GSK3B glycogen synthase kinase 3 beta -2.36872
CARM1 coactivator-associated arginine methyltransferase 1 -2.361
TSR3 TSR3, 20S rRNA accumulation, homolog (S. cerevisiae) -2.34121
GDF15 growth differentiation factor 15 -2.27354
MSL1 male-specific lethal 1 homolog (Drosophila) -2.229
STXBP2 syntaxin binding protein 2 -2.21604
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 -2.14611
DDRGK1 DDRGK domain containing 1 -2.12994
NSFL1C NSFL1 (p97) cofactor (p47) -2.09899
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -2.09303
PLAG1 pleiomorphic adenoma gene 1 -2.0505
ZNF133 zinc finger protein 133 -2.04583
ANKMY2 ankyrin repeat and MYND domain containing 2 -2.0287
FKBP14 FK506 binding protein 14, 22 kDa -2.02565
FHOD1 formin homology 2 domain containing 1 -2.00362