CRCGN016_MCF10A.WT.HP_24H:H04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description p-nitroaniline 100.46 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

40 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:H04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGR2 anterior gradient 2 5.39754
TRIB3 tribbles pseudokinase 3 4.3868
KCTD5 potassium channel tetramerization domain containing 5 4.06569
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 3.62446
INSIG1 insulin induced gene 1 3.39757
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 3.3816
CXCL2 chemokine (C-X-C motif) ligand 2 3.03238
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.83962
SQSTM1 sequestosome 1 2.78091
NFIL3 nuclear factor, interleukin 3 regulated 2.65581
SH3D19 SH3 domain containing 19 2.45949
ASNS asparagine synthetase (glutamine-hydrolyzing) 2.40721
LOC128125814 uncharacterized LOC128125814 2.22915
PHGDH phosphoglycerate dehydrogenase 2.22744
TXNL4B thioredoxin-like 4B 2.14084
GLRX glutaredoxin (thioltransferase) 2.14034
HMOX1 heme oxygenase 1 2.13174
TNIP1 TNFAIP3 interacting protein 1 2.11076
DDIT4 DNA-damage-inducible transcript 4 2.07729
NUCB2 nucleobindin 2 2.07631
FOXO4 forkhead box O4 2.05489
ADGRE5 adhesion G protein-coupled receptor E5 2.03441
ACAA1 acetyl-CoA acyltransferase 1 2.0275
AARS1 alanyl-tRNA synthetase 1 2.0263
ARID5B AT rich interactive domain 5B (MRF1-like) 2.02262
ACLY ATP citrate lyase 2.01835
PSAT1 phosphoserine aminotransferase 1 2.00613

decreased expression

Symbol Name Standardized Value
PMM2 phosphomannomutase 2 -3.97845
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.86529
CCNB2 cyclin B2 -3.78379
S100A8 S100 calcium binding protein A8 -3.59826
CHIC2 cysteine-rich hydrophobic domain 2 -2.82147
MCM3 minichromosome maintenance complex component 3 -2.57052
RALGDS ral guanine nucleotide dissociation stimulator -2.38368
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.34325
BASP1 brain abundant, membrane attached signal protein 1 -2.2332
SPEF1 sperm flagellar 1 -2.12231
TLCD3A TLC domain containing 3A -2.08932
CRB1 crumbs family member 1, photoreceptor morphogenesis associated -2.0277
EPB41L4A erythrocyte membrane protein band 4.1 like 4A -2.00443