CRCGN016_MCF10A.WT.HP_24H:H15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description barium chloride dihydrate 11.33 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

46 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:H15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADGRE5 adhesion G protein-coupled receptor E5 5.9411
PRKCH protein kinase C, eta 4.62625
LAGE3 L antigen family, member 3 4.37056
AGR2 anterior gradient 2 4.31953
ABHD4 abhydrolase domain containing 4 4.0285
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 4.01939
RPP38 ribonuclease P/MRP 38kDa subunit 3.15664
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.87142
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.84552
NCOA1 nuclear receptor coactivator 1 2.12013
CCT4 chaperonin containing TCP1, subunit 4 (delta) 2.10162
ACAA1 acetyl-CoA acyltransferase 1 2.09603
MAGEA10 melanoma antigen family A10 2.04222

decreased expression

Symbol Name Standardized Value
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -4.77607
THAP11 THAP domain containing 11 -4.37934
MAPK13 mitogen-activated protein kinase 13 -4.3514
BASP1 brain abundant, membrane attached signal protein 1 -4.19695
CCNB2 cyclin B2 -4.00034
S100A8 S100 calcium binding protein A8 -3.85797
HMG20B high mobility group 20B -3.62978
S100A6 S100 calcium binding protein A6 -3.57457
VDAC1 voltage-dependent anion channel 1 -3.56467
JMJD6 jumonji domain containing 6 -3.26196
BPHL biphenyl hydrolase-like (serine hydrolase) -3.15343
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.99784
GDF15 growth differentiation factor 15 -2.86176
USP3 ubiquitin specific peptidase 3 -2.77785
ZNF34 zinc finger protein 34 -2.64128
OAT ornithine aminotransferase -2.62105
RGS2 regulator of G-protein signaling 2 -2.56969
RNF111 ring finger protein 111 -2.52585
TENT4A terminal nucleotidyltransferase 4A -2.51228
ARID4B AT rich interactive domain 4B (RBP1-like) -2.49495
CHP2 calcineurin-like EF-hand protein 2 -2.46348
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.44875
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.3827
ADIRF adipogenesis regulatory factor -2.33885
TRIB3 tribbles pseudokinase 3 -2.28456
RPAP2 RNA polymerase II associated protein 2 -2.2022
MOSPD3 motile sperm domain containing 3 -2.19527
PARP6 poly (ADP-ribose) polymerase family, member 6 -2.19279
POLG2 polymerase (DNA directed), gamma 2, accessory subunit -2.12718
FLCN folliculin -2.0868
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 -2.07634
SIAH1 siah E3 ubiquitin protein ligase 1 -2.05504
HMG20A high mobility group 20A -2.00482