CRCGN016_MCF10A.WT.HP_24H:H16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tert-butylhydroquinone 100.97 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

65 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:H16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 7.98355
AGR2 anterior gradient 2 5.90696
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 4.69729
UGDH UDP-glucose 6-dehydrogenase 4.55608
GCLM glutamate-cysteine ligase, modifier subunit 4.41028
HMOX1 heme oxygenase 1 4.0399
IGFBP3 insulin-like growth factor binding protein 3 3.72847
CBR3 carbonyl reductase 3 3.35325
GLRX glutaredoxin (thioltransferase) 3.25904
CTSL cathepsin L 3.21209
NQO1 NAD(P)H dehydrogenase, quinone 1 3.16038
SQSTM1 sequestosome 1 3.14512
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 3.06192
GSR glutathione reductase 3.00281
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.85396
TSKU tsukushi, small leucine rich proteoglycan 2.83607
VGLL4 vestigial-like family member 4 2.82218
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 2.78188
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.76079
KEAP1 kelch-like ECH-associated protein 1 2.64558
PIR pirin (iron-binding nuclear protein) 2.61208
TRIM16 tripartite motif containing 16 2.5559
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.48911
ABHD4 abhydrolase domain containing 4 2.47629
RPP38 ribonuclease P/MRP 38kDa subunit 2.39541
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.31511
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.2492
CES1 carboxylesterase 1 2.17276
OLFML2B olfactomedin-like 2B 2.15653
GCLC glutamate-cysteine ligase, catalytic subunit 2.1415
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 2.09965
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated 2.07808
HLA-DMA major histocompatibility complex, class II, DM alpha 2.07321
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 2.06243
TMEM248 transmembrane protein 248 2.05976
CENPE centromere protein E, 312kDa 2.03475
PCDHB16 protocadherin beta 16 2.0304

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -4.19447
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.69112
TXNDC9 thioredoxin domain containing 9 -3.58456
PRPF4 pre-mRNA processing factor 4 -3.23735
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.57914
TMEM115 transmembrane protein 115 -2.55757
SGK1 serum/glucocorticoid regulated kinase 1 -2.48426
NISCH nischarin -2.47707
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor -2.45964
BPHL biphenyl hydrolase-like (serine hydrolase) -2.42534
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) -2.19558
ACAA1 acetyl-CoA acyltransferase 1 -2.15357
IFRD2 interferon-related developmental regulator 2 -2.1261
BCKDK branched chain ketoacid dehydrogenase kinase -2.12097
SLC12A9 solute carrier family 12, member 9 -2.11955
NOTCH1 notch 1 -2.11809
DCAF10 DDB1 and CUL4 associated factor 10 -2.11145
S100A4 S100 calcium binding protein A4 -2.08935
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.08447
RAB17 RAB17, member RAS oncogene family -2.076
RAB3A RAB3A, member RAS oncogene family -2.055
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) -2.0422
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 -2.02085
SOSTDC1 sclerostin domain containing 1 -2.01836
TMBIM4 transmembrane BAX inhibitor motif containing 4 -2.01173
APEH acylaminoacyl-peptide hydrolase -2.0095
LAMP3 lysosomal-associated membrane protein 3 -2.00282
KAT2A K(lysine) acetyltransferase 2A -2.00028