CRCGN016_MCF10A.WT.HP_24H:H17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tert-butylhydroquinone 33.66 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

102 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:H17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABHD6 abhydrolase domain containing 6 6.32644
TXNRD1 thioredoxin reductase 1 5.30421
EVL Enah/Vasp-like 4.31771
AXIN1 axin 1 4.01012
OLFML2B olfactomedin-like 2B 3.60274
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 3.59371
DHRS2 dehydrogenase/reductase (SDR family) member 2 3.59026
PRKCQ protein kinase C, theta 3.30209
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.28811
CLNS1A chloride channel, nucleotide-sensitive, 1A 2.95679
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 2.87859
GRB10 growth factor receptor-bound protein 10 2.83452
ALG8 ALG8, alpha-1,3-glucosyltransferase 2.72962
AGR2 anterior gradient 2 2.61605
PTPRG protein tyrosine phosphatase, receptor type, G 2.61362
TLCD3A TLC domain containing 3A 2.59251
THAP12 THAP domain containing 12 2.56772
NCK2 NCK adaptor protein 2 2.51368
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.47008
RCAN3 RCAN family member 3 2.36096
MAGED4B melanoma antigen family D4B 2.34843
TGFBR1 transforming growth factor, beta receptor 1 2.31127
MAPK9 mitogen-activated protein kinase 9 2.22948
PEX11A peroxisomal biogenesis factor 11 alpha 2.22069
RPAIN RPA interacting protein 2.21411
GATA3 GATA binding protein 3 2.18023
IPO5 importin 5 2.17025
NPC1 Niemann-Pick disease, type C1 2.13216
SQSTM1 sequestosome 1 2.10707
HMGA2 high mobility group AT-hook 2 2.0996
PKN1 protein kinase N1 2.07507
MRPL3 mitochondrial ribosomal protein L3 2.06723
ZPR1 ZPR1 zinc finger 2.06536
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B 2.03652
FHOD1 formin homology 2 domain containing 1 2.03073
TBP TATA box binding protein 2.02249
COX17 COX17 cytochrome c oxidase copper chaperone 2.0178
PRR5L proline rich 5 like 2.01733
CCNA1 cyclin A1 2.00993
CBR3 carbonyl reductase 3 2.00447
OLFML3 olfactomedin-like 3 2.00331

decreased expression

Symbol Name Standardized Value
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.74712
BASP1 brain abundant, membrane attached signal protein 1 -3.68078
GDF15 growth differentiation factor 15 -3.64399
RNF167 ring finger protein 167 -3.63525
CCNB1 cyclin B1 -3.25051
KRT14 keratin 14, type I -3.2404
RPIA ribose 5-phosphate isomerase A -3.01313
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 -2.85007
S100A4 S100 calcium binding protein A4 -2.81953
CDC45 cell division cycle 45 -2.80383
BAG3 BCL2-associated athanogene 3 -2.76319
UNC93B1 unc-93 homolog B1 (C. elegans) -2.74252
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.72563
RPA3 replication protein A3, 14kDa -2.59629
KIF14 kinesin family member 14 -2.58544
FMR1 fragile X mental retardation 1 -2.51028
MOSPD3 motile sperm domain containing 3 -2.48346
MSMO1 methylsterol monooxygenase 1 -2.44774
MT1X metallothionein 1X -2.43494
PRSS8 protease, serine, 8 -2.42818
PRR15L proline rich 15-like -2.42649
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 -2.3718
ARID4B AT rich interactive domain 4B (RBP1-like) -2.37143
BID BH3 interacting domain death agonist -2.34468
STXBP2 syntaxin binding protein 2 -2.30576
NXPH3 neurexophilin 3 -2.28782
CTF1 cardiotrophin 1 -2.28337
ARPP21 cAMP-regulated phosphoprotein, 21kDa -2.26891
ETV7 ets variant 7 -2.26325
PADI1 peptidyl arginine deiminase, type I -2.2581
ALOX5 arachidonate 5-lipoxygenase -2.2544
PPL periplakin -2.25423
PRPF4 pre-mRNA processing factor 4 -2.25241
AMN amnion associated transmembrane protein -2.25043
HCK HCK proto-oncogene, Src family tyrosine kinase -2.23796
TCF15 transcription factor 15 (basic helix-loop-helix) -2.22588
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 -2.22372
KRT23 keratin 23, type I -2.20418
LIMS2 LIM and senescent cell antigen-like domains 2 -2.18687
ARPP19 cAMP-regulated phosphoprotein, 19kDa -2.18515
HPCA hippocalcin -2.17929
A4GALT alpha 1,4-galactosyltransferase -2.17577
KIAA0319L KIAA0319-like -2.17207
FICD FIC domain containing -2.16799
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma -2.16717
TMEM106B transmembrane protein 106B -2.16139
PRX periaxin -2.15035
GDF2 growth differentiation factor 2 -2.12252
ZNF358 zinc finger protein 358 -2.11489
MTFR1 mitochondrial fission regulator 1 -2.10724
PLD2 phospholipase D2 -2.09166
ADGRD2 adhesion G protein-coupled receptor D2 -2.08013
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa -2.07416
BBC3 BCL2 binding component 3 -2.07022
AQP1 aquaporin 1 (Colton blood group) -2.06591
EOLA1 endothelium and lymphocyte associated ASCH domain 1 -2.05357
SEMA6C sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C -2.05192
VAMP7 vesicle-associated membrane protein 7 -2.04737
NIBAN1 niban apoptosis regulator 1 -2.01851
SOD3 superoxide dismutase 3, extracellular -2.01075
HSPB1 heat shock 27kDa protein 1 -2.00401