CRCGN016_MCF10A.WT.HP_24H:H19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description estriol 101.96 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

43 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:H19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 4.01182
AMDHD2 amidohydrolase domain containing 2 3.03436
ZNF586 zinc finger protein 586 2.99094
DENND2D DENN/MADD domain containing 2D 2.92328
GRB10 growth factor receptor-bound protein 10 2.83314
MICALL1 MICAL-like 1 2.66958
OLFML2B olfactomedin-like 2B 2.453
HOXA5 homeobox A5 2.37078
HMGA2 high mobility group AT-hook 2 2.28416
AGR2 anterior gradient 2 2.09664
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 2.09414
AHCYL1 adenosylhomocysteinase-like 1 2.08666
GCLM glutamate-cysteine ligase, modifier subunit 2.06475
PTK2 protein tyrosine kinase 2 2.00535

decreased expression

Symbol Name Standardized Value
TXNDC9 thioredoxin domain containing 9 -7.11208
SGK1 serum/glucocorticoid regulated kinase 1 -5.59111
KRT14 keratin 14, type I -4.98297
DYNLT3 dynein, light chain, Tctex-type 3 -3.3759
PLK1 polo-like kinase 1 -3.21229
PRCP prolylcarboxypeptidase (angiotensinase C) -3.19239
STARD7 StAR-related lipid transfer (START) domain containing 7 -3.0216
GDF15 growth differentiation factor 15 -2.94106
CYCS cytochrome c, somatic -2.78223
HSPA8 heat shock 70kDa protein 8 -2.76303
UNC50 unc-50 homolog (C. elegans) -2.70534
COXFA4 cytochrome c oxidase associated subunit FA4 -2.62353
DNM1L dynamin 1-like -2.50578
REV1 REV1, polymerase (DNA directed) -2.50081
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.50001
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria -2.4933
THAP11 THAP domain containing 11 -2.44197
PRR15L proline rich 15-like -2.37468
PDCD10 programmed cell death 10 -2.33747
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.17799
COX5B cytochrome c oxidase subunit Vb -2.17193
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) -2.16178
EVC Ellis van Creveld protein -2.16143
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2 -2.09883
EIF5B eukaryotic translation initiation factor 5B -2.06155
JUP junction plakoglobin -2.05236
JADE2 jade family PHD finger 2 -2.0181
FRMPD4 FERM and PDZ domain containing 4 -2.01636
CRYM crystallin, mu -2.01617