CRCGN016_MCF10A.WT.HP_24H:H20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description estriol 33.99 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

53 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:H20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TBX2 T-box 2 5.29195
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.92412
ZW10 zw10 kinetochore protein 4.8775
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.72929
PECR peroxisomal trans-2-enoyl-CoA reductase 3.26883
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa 2.86005
BACE2 beta-site APP-cleaving enzyme 2 2.71635
KLHL21 kelch-like family member 21 2.43956
CHN1 chimerin 1 2.32583
SPC25 SPC25, NDC80 kinetochore complex component 2.30647
SATB1 SATB homeobox 1 2.27481
HIKESHI heat shock protein nuclear import factor hikeshi 2.26716
ECHDC1 ethylmalonyl-CoA decarboxylase 1 2.15374
EVL Enah/Vasp-like 2.1236
RBM7 RNA binding motif protein 7 2.1226
CADM1 cell adhesion molecule 1 2.09563
UBA2 ubiquitin-like modifier activating enzyme 2 2.07518
EDNRB endothelin receptor type B 2.01598

decreased expression

Symbol Name Standardized Value
TIMP1 TIMP metallopeptidase inhibitor 1 -5.80492
MRPS2 mitochondrial ribosomal protein S2 -5.30367
UBE3C ubiquitin protein ligase E3C -4.86756
COG7 component of oligomeric golgi complex 7 -4.817
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.65776
WASHC4 WASH complex subunit 4 -3.59623
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 -3.41557
GDF15 growth differentiation factor 15 -3.36714
PPP1R26 protein phosphatase 1, regulatory subunit 26 -3.0383
GNAS GNAS complex locus -2.96724
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing -2.902
NUSAP1 nucleolar and spindle associated protein 1 -2.65621
ATP5F1E ATP synthase F1 subunit epsilon -2.62775
SEC16A SEC16 homolog A (S. cerevisiae) -2.55082
PMPCA peptidase (mitochondrial processing) alpha -2.53925
MAN1B1 mannosidase, alpha, class 1B, member 1 -2.52609
POMT1 protein-O-mannosyltransferase 1 -2.44479
UBB ubiquitin B -2.43784
NELFB negative elongation factor complex member B -2.43778
BASP1 brain abundant, membrane attached signal protein 1 -2.40527
UBAC1 UBA domain containing 1 -2.30846
EDF1 endothelial differentiation-related factor 1 -2.29864
MT1X metallothionein 1X -2.27132
CHAD chondroadherin -2.24182
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) -2.23207
ACAA1 acetyl-CoA acyltransferase 1 -2.22285
LRP5 low density lipoprotein receptor-related protein 5 -2.17841
ANAPC2 anaphase promoting complex subunit 2 -2.1624
FTCD formimidoyltransferase cyclodeaminase -2.09643
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) -2.08718
DAZ2 deleted in azoospermia 2 -2.07857
TSC1 tuberous sclerosis 1 -2.05645
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 -2.04206
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) -2.03043
TRIP6 thyroid hormone receptor interactor 6 -2.02167