CRCGN016_MCF10A.WT.HP_24H:H23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,2-bis(bromomethyl)-1,3-pro?panediol, technical grade 34.02 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:H23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ACAA1 acetyl-CoA acyltransferase 1 3.68507
COMP cartilage oligomeric matrix protein 3.43475
CLNS1A chloride channel, nucleotide-sensitive, 1A 3.25842
RSF1 remodeling and spacing factor 1 3.07549
EMSY EMSY transcriptional repressor, BRCA2 interacting 2.87746
SNX11 sorting nexin 11 2.7159
IGHMBP2 immunoglobulin mu binding protein 2 2.68278
PRKCH protein kinase C, eta 2.56615
AAMDC adipogenesis associated, Mth938 domain containing 2.54859
DENND2D DENN/MADD domain containing 2D 2.49133
PARP8 poly (ADP-ribose) polymerase family, member 8 2.42557
TLN1 talin 1 2.36946
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 2.33131
PKN1 protein kinase N1 2.32659
CBX1 chromobox homolog 1 2.27163
PECR peroxisomal trans-2-enoyl-CoA reductase 2.24564
PTMS parathymosin 2.24423
HBB hemoglobin, beta 2.23355
HAUS6 HAUS augmin-like complex, subunit 6 2.16492
HBA1 hemoglobin, alpha 1 2.13674
BICRA BRD4 interacting chromatin remodeling complex associated protein 2.11038
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.10673
BAHD1 bromo adjacent homology domain containing 1 2.06475
UVRAG UV radiation resistance associated 2.0516
AFAP1 actin filament associated protein 1 2.0414

decreased expression

Symbol Name Standardized Value
GDF15 growth differentiation factor 15 -4.75056
FABP5 fatty acid binding protein 5 (psoriasis-associated) -3.73634
COG7 component of oligomeric golgi complex 7 -3.58498
HAT1 histone acetyltransferase 1 -3.58264
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.51116
SLC35F2 solute carrier family 35, member F2 -3.34765
PUF60 poly-U binding splicing factor 60KDa -3.3342
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.16805
TSPAN4 tetraspanin 4 -3.06335
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.03643
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.82129
MRPS2 mitochondrial ribosomal protein S2 -2.57629
TOMM34 translocase of outer mitochondrial membrane 34 -2.43815
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.40437
METTL9 methyltransferase like 9 -2.35549
BASP1 brain abundant, membrane attached signal protein 1 -2.32208
TSPYL5 TSPY-like 5 -2.25652
DCTN5 dynactin 5 (p25) -2.24522
NPY5R neuropeptide Y receptor Y5 -2.22027
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 -2.17253
ACTR10 actin-related protein 10 homolog (S. cerevisiae) -2.13351
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.10721
EIF3I eukaryotic translation initiation factor 3, subunit I -2.0719