CRCGN016_MCF10A.WT.HP_24H:I01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methoxychlor 100.97 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

68 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:I01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NOTCH1 notch 1 4.40286
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.06178
ACAA1 acetyl-CoA acyltransferase 1 3.73799
NCK2 NCK adaptor protein 2 3.27039
EPN2 epsin 2 3.14412
HAT1 histone acetyltransferase 1 2.84384
SYNGAP1 synaptic Ras GTPase activating protein 1 2.83138
AGR2 anterior gradient 2 2.81283
PRR7 proline rich 7 (synaptic) 2.74179
SLC12A9 solute carrier family 12, member 9 2.6968
MDM4 MDM4, p53 regulator 2.62087
MTA2 metastasis associated 1 family, member 2 2.46459
RBBP5 retinoblastoma binding protein 5 2.44328
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.35487
ALG3 ALG3, alpha-1,3- mannosyltransferase 2.31529
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.23732
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 2.22134
TSKU tsukushi, small leucine rich proteoglycan 2.18794
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.17386
SLC75A1 solute carrier family 75 member 1 2.17073
XPO6 exportin 6 2.1707
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.13349
NELFA negative elongation factor complex member A 2.11459

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -5.05493
PARP2 poly (ADP-ribose) polymerase 2 -4.26792
YME1L1 YME1-like 1 ATPase -4.04986
TIMP1 TIMP metallopeptidase inhibitor 1 -3.62777
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.55098
GADD45B growth arrest and DNA-damage-inducible, beta -3.47403
GTPBP8 GTP-binding protein 8 (putative) -3.4099
PGAM4 phosphoglycerate mutase family member 4 -3.20196
ALDOC aldolase C, fructose-bisphosphate -3.17101
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.96249
ANXA2 annexin A2 -2.96141
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.92571
BPHL biphenyl hydrolase-like (serine hydrolase) -2.81262
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.80786
INSIG1 insulin induced gene 1 -2.61106
SH3D19 SH3 domain containing 19 -2.6088
SOAT2 sterol O-acyltransferase 2 -2.56998
ASCC1 activating signal cointegrator 1 complex subunit 1 -2.56791
ECH1 enoyl CoA hydratase 1, peroxisomal -2.53685
MSRB2 methionine sulfoxide reductase B2 -2.49157
PFDN1 prefoldin subunit 1 -2.4087
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.36449
OSGEP O-sialoglycoprotein endopeptidase -2.32425
ZNF248 zinc finger protein 248 -2.26071
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 -2.24035
MINDY3 MINDY lysine 48 deubiquitinase 3 -2.23765
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein -2.1989
THNSL1 threonine synthase-like 1 (S. cerevisiae) -2.1726
MTPAP mitochondrial poly(A) polymerase -2.17171
ENO2 enolase 2 (gamma, neuronal) -2.15348
RAB33A RAB33A, member RAS oncogene family -2.14067
GOLT1B golgi transport 1B -2.1367
DAD1 defender against cell death 1 -2.10809
CDK7 cyclin-dependent kinase 7 -2.10259
ACLY ATP citrate lyase -2.09194
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.08703
GLO1 glyoxalase I -2.08085
PELO pelota homolog (Drosophila) -2.07555
NXF3 nuclear RNA export factor 3 -2.07156
DAAM1 dishevelled associated activator of morphogenesis 1 -2.04407
TMEM242 transmembrane protein 242 -2.02306
ERG28 ergosterol biosynthesis 28 homolog -2.02237
ARID3B AT rich interactive domain 3B (BRIGHT-like) -2.02181
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) -2.02069
THBS4 thrombospondin 4 -2.02013