CRCGN016_MCF10A.WT.HP_24H:I11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description p-chloroaniline 33.43 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

58 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:I11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 4.59175
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.7687
ACAA1 acetyl-CoA acyltransferase 1 3.3554
E2F2 E2F transcription factor 2 3.02247
DDR1 discoidin domain receptor tyrosine kinase 1 3.00985
RAB11FIP2 RAB11 family interacting protein 2 (class I) 2.83594
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.74395
IGHMBP2 immunoglobulin mu binding protein 2 2.72674
MELK maternal embryonic leucine zipper kinase 2.62925
SBNO1 strawberry notch homolog 1 (Drosophila) 2.56756
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.55923
SSNA1 Sjogren syndrome nuclear autoantigen 1 2.54392
MTA2 metastasis associated 1 family, member 2 2.51335
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa 2.4766
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.46179
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.38702
KDM5D lysine (K)-specific demethylase 5D 2.37958
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.35489
CIRBP cold inducible RNA binding protein 2.33063
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 2.28758
COMP cartilage oligomeric matrix protein 2.26727
SNX17 sorting nexin 17 2.24735
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 2.20984
STK32B serine/threonine kinase 32B 2.18093
NSUN3 NOP2/Sun domain family, member 3 2.16337
OXSM 3-oxoacyl-ACP synthase, mitochondrial 2.15068
ZNF443 zinc finger protein 443 2.124
RBM47 RNA binding motif protein 47 2.08082
COMMD8 COMM domain containing 8 2.07832
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 2.06394
RPL10L ribosomal protein L10-like 2.0614
RBBP5 retinoblastoma binding protein 5 2.04977
PDIA5 protein disulfide isomerase family A, member 5 2.03566
SNAP25 synaptosomal-associated protein, 25kDa 2.01892
TEX264 testis expressed 264 2.00862
BACE2 beta-site APP-cleaving enzyme 2 2.0056

decreased expression

Symbol Name Standardized Value
BASP1 brain abundant, membrane attached signal protein 1 -4.61421
HAT1 histone acetyltransferase 1 -3.56477
ARID4B AT rich interactive domain 4B (RBP1-like) -3.50333
THAP11 THAP domain containing 11 -3.39008
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.37623
GNAS GNAS complex locus -3.30238
GDF15 growth differentiation factor 15 -2.99098
MACF1 microtubule-actin crosslinking factor 1 -2.75009
CD58 CD58 molecule -2.62646
BAG3 BCL2-associated athanogene 3 -2.55629
SMC1A structural maintenance of chromosomes 1A -2.40091
TENT4A terminal nucleotidyltransferase 4A -2.34398
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) -2.23228
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) -2.2234
ITPKB inositol-trisphosphate 3-kinase B -2.21817
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.15154
PGAP6 post-GPI attachment to proteins 6 -2.14746
OXA1L oxidase (cytochrome c) assembly 1-like -2.14238
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -2.08774
RGL2 ral guanine nucleotide dissociation stimulator-like 2 -2.05563
SGK1 serum/glucocorticoid regulated kinase 1 -2.03281
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked -2.00947