CRCGN016_MCF10A.WT.HP_24H:I20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,2-dichlorobenzene 33.6 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

41 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:I20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PEX11A peroxisomal biogenesis factor 11 alpha 3.94914
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.68927
STK10 serine/threonine kinase 10 3.56544
MAP7 microtubule-associated protein 7 3.16475
SNAP25 synaptosomal-associated protein, 25kDa 3.10487
CORO1A coronin, actin binding protein, 1A 3.00752
SYNE2 spectrin repeat containing, nuclear envelope 2 2.93533
CERK ceramide kinase 2.90374
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 2.82587
TBX2 T-box 2 2.8009
CXCL2 chemokine (C-X-C motif) ligand 2 2.77913
ALAS1 5'-aminolevulinate synthase 1 2.62863
NID2 nidogen 2 (osteonidogen) 2.4772
LGMN legumain 2.45827
RTN2 reticulon 2 2.39792
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.34939
INSM1 insulinoma-associated 1 2.308
ATP11B ATPase, class VI, type 11B 2.21465
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.1796
NOTCH4 notch 4 2.16757
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.16521
AGR2 anterior gradient 2 2.15318
MAP3K5 mitogen-activated protein kinase kinase kinase 5 2.13465
MAD2L1BP MAD2L1 binding protein 2.06657
TSPAN15 tetraspanin 15 2.0211

decreased expression

Symbol Name Standardized Value
TIMP1 TIMP metallopeptidase inhibitor 1 -4.77445
GDF15 growth differentiation factor 15 -4.21866
ACOT9 acyl-CoA thioesterase 9 -3.95994
TSPAN4 tetraspanin 4 -3.68771
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.34915
SMNDC1 survival motor neuron domain containing 1 -3.31015
TXNDC9 thioredoxin domain containing 9 -3.26518
MELK maternal embryonic leucine zipper kinase -3.04908
TLK2 tousled-like kinase 2 -2.54187
NT5DC2 5'-nucleotidase domain containing 2 -2.37816
THAP11 THAP domain containing 11 -2.2692
RRAGA Ras-related GTP binding A -2.17222
RXYLT1 ribitol xylosyltransferase 1 -2.14199
ACAA1 acetyl-CoA acyltransferase 1 -2.09158
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa -2.05278
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 -2.00806