CRCGN016_MCF10A.WT.HP_24H:J02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tiabendazole 33.82 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

32 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:J02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 5.24678
VAV3 vav 3 guanine nucleotide exchange factor 3.99215
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.73156
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.72703
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.48761
STAP2 signal transducing adaptor family member 2 3.43908
MAMLD1 mastermind-like domain containing 1 3.1922
CNPY3 canopy FGF signaling regulator 3 3.17503
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 2.65936
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.59649
C5 complement component 5 2.52981
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.20797
ZNF589 zinc finger protein 589 2.10308
KLRC1 killer cell lectin-like receptor subfamily C, member 1 2.07525
ARAF A-Raf proto-oncogene, serine/threonine kinase 2.06871
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.02673

decreased expression

Symbol Name Standardized Value
RPIA ribose 5-phosphate isomerase A -4.61683
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.92094
UBE3C ubiquitin protein ligase E3C -3.46864
GDF15 growth differentiation factor 15 -3.22601
HEATR1 HEAT repeat containing 1 -3.11598
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa -3.02262
ARID4B AT rich interactive domain 4B (RBP1-like) -2.78837
PSIP1 PC4 and SFRS1 interacting protein 1 -2.69348
LRP10 low density lipoprotein receptor-related protein 10 -2.32966
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -2.19154
SARAF store-operated calcium entry-associated regulatory factor -2.16192
MT1X metallothionein 1X -2.0753
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.05691
GSR glutathione reductase -2.05478
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.02391
CD151 CD151 molecule (Raph blood group) -2.0089