CRCGN016_MCF10A.WT.HP_24H:J03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tiabendazole 11.27 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

59 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:J03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MEF2C myocyte enhancer factor 2C 5.137
ARID5B AT rich interactive domain 5B (MRF1-like) 4.78069
SNAP25 synaptosomal-associated protein, 25kDa 4.54773
ACAA1 acetyl-CoA acyltransferase 1 3.3297
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 3.23432
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.99219
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 2.85869
OLFM1 olfactomedin 1 2.71527
SNCB synuclein, beta 2.68728
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 2.6774
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 2.5834
SLC30A10 solute carrier family 30, member 10 2.542
GIMAP6 GTPase, IMAP family member 6 2.49043
GADD45A growth arrest and DNA-damage-inducible, alpha 2.45443
NRXN1 neurexin 1 2.44127
SCN1A sodium channel, voltage gated, type I alpha subunit 2.41174
CYBRD1 cytochrome b reductase 1 2.37509
DCLK1 doublecortin-like kinase 1 2.33768
SH3GL2 SH3-domain GRB2-like 2 2.32896
BSN bassoon presynaptic cytomatrix protein 2.3286
ARHGAP29 Rho GTPase activating protein 29 2.29294
NRN1 neuritin 1 2.27725
PLSCR3 phospholipid scramblase 3 2.25331
SNAP91 synaptosomal-associated protein, 91kDa 2.21418
NSG2 neuronal vesicle trafficking associated 2 2.20662
RNF146 ring finger protein 146 2.20555
ADTRP androgen-dependent TFPI-regulating protein 2.19124
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.17551
STMN2 stathmin 2 2.16472
NTSR2 neurotensin receptor 2 2.15431
CLEC2D C-type lectin domain family 2, member D 2.12343
AADAC arylacetamide deacetylase 2.08375
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.07973
GIMAP4 GTPase, IMAP family member 4 2.07108
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 2.0605
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 2.04185
RERGL RERG/RAS-like 2.02379

decreased expression

Symbol Name Standardized Value
TXNDC9 thioredoxin domain containing 9 -4.69663
CHMP4B charged multivesicular body protein 4B -4.26077
JMJD6 jumonji domain containing 6 -3.99915
RXYLT1 ribitol xylosyltransferase 1 -3.63569
PMM2 phosphomannomutase 2 -3.28946
REEP5 receptor accessory protein 5 -2.81878
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -2.76187
SAP30BP SAP30 binding protein -2.68564
MXRA7 matrix-remodelling associated 7 -2.68463
AKAP8 A kinase (PRKA) anchor protein 8 -2.61639
XPO7 exportin 7 -2.38466
TRAP1 TNF receptor-associated protein 1 -2.26633
CXCL8 chemokine (C-X-C motif) ligand 8 -2.26261
GOLPH3L golgi phosphoprotein 3-like -2.16614
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide -2.13684
PRPF3 pre-mRNA processing factor 3 -2.11018
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.10815
TYROBP TYRO protein tyrosine kinase binding protein -2.07789
REV1 REV1, polymerase (DNA directed) -2.05389
USP36 ubiquitin specific peptidase 36 -2.05371
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.05231
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.03192