CRCGN016_MCF10A.WT.HP_24H:J05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dioxane 34.33 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

134 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:J05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGR2 anterior gradient 2 4.95315
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.34993
STAP2 signal transducing adaptor family member 2 3.63688
COMP cartilage oligomeric matrix protein 3.10094
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.92054
CFAP20 cilia and flagella associated protein 20 2.73761
GARRE1 granule associated Rac and RHOG effector 1 2.68235
TMEM231 transmembrane protein 231 2.46944
BACE2 beta-site APP-cleaving enzyme 2 2.31347
NAE1 NEDD8 activating enzyme E1 subunit 1 2.22166
TXNL4B thioredoxin-like 4B 2.19243
CFAP298 cilia and flagella associated protein 298 2.10617
DCPS decapping enzyme, scavenger 2.10182
IFT88 intraflagellar transport 88 2.06792

decreased expression

Symbol Name Standardized Value
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.89105
KRT14 keratin 14, type I -4.7026
GDF15 growth differentiation factor 15 -4.38468
CCDC86 coiled-coil domain containing 86 -4.33721
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -4.30004
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -4.14405
BASP1 brain abundant, membrane attached signal protein 1 -2.94213
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -2.76125
NUP88 nucleoporin 88kDa -2.75067
CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase) -2.57023
RRH retinal pigment epithelium-derived rhodopsin homolog -2.54584
CLEC16A C-type lectin domain family 16, member A -2.51417
CTNNA3 catenin (cadherin-associated protein), alpha 3 -2.491
EIF2D eukaryotic translation initiation factor 2D -2.47499
PARD6B par-6 family cell polarity regulator beta -2.46474
PLA2G3 phospholipase A2, group III -2.46257
CBX2 chromobox homolog 2 -2.44898
IFNA7 interferon, alpha 7 -2.44154
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) -2.42046
SCN5A sodium channel, voltage gated, type V alpha subunit -2.41844
LHX3 LIM homeobox 3 -2.41422
ALLC allantoicase -2.40771
FHIT fragile histidine triad -2.3968
RIPPLY3 ripply transcriptional repressor 3 -2.39507
DTX4 deltex 4, E3 ubiquitin ligase -2.38466
WNT11 wingless-type MMTV integration site family, member 11 -2.36122
ARID4B AT rich interactive domain 4B (RBP1-like) -2.35603
DNASE1L2 deoxyribonuclease I-like 2 -2.33431
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.32997
ACTR10 actin-related protein 10 homolog (S. cerevisiae) -2.3237
SLC14A2 solute carrier family 14 (urea transporter), member 2 -2.31443
HKDC1 hexokinase domain containing 1 -2.31218
NALF2 NALCN channel auxiliary factor 2 -2.30576
FRMD1 FERM domain containing 1 -2.30449
MTNR1A melatonin receptor 1A -2.29964
SLC13A4 solute carrier family 13 (sodium/sulfate symporter), member 4 -2.28701
OR1D2 olfactory receptor, family 1, subfamily D, member 2 -2.27863
CETN1 centrin, EF-hand protein, 1 -2.27748
RNF208 ring finger protein 208 -2.25911
ZBTB7B zinc finger and BTB domain containing 7B -2.25709
OR1E1 olfactory receptor, family 1, subfamily E, member 1 -2.2422
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 -2.23696
GML glycosylphosphatidylinositol anchored molecule like -2.22685
ALOX12B arachidonate 12-lipoxygenase, 12R type -2.22246
HLA-DOB major histocompatibility complex, class II, DO beta -2.21111
MT1X metallothionein 1X -2.19141
SPMAP2 sperm microtubule associated protein 2 -2.18983
SZT2 seizure threshold 2 homolog (mouse) -2.18782
CHRM2 cholinergic receptor, muscarinic 2 -2.17226
PGM5 phosphoglucomutase 5 -2.16984
PRKG2 protein kinase, cGMP-dependent, type II -2.16506
FLRT1 fibronectin leucine rich transmembrane protein 1 -2.14782
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 -2.14538
TDRD1 tudor domain containing 1 -2.14478
OR5I1 olfactory receptor, family 5, subfamily I, member 1 -2.13821
LRRC8D leucine rich repeat containing 8 family, member D -2.13594
TMC7 transmembrane channel-like 7 -2.1321
PPP1R17 protein phosphatase 1, regulatory subunit 17 -2.12863
NEO1 neogenin 1 -2.12333
LMO3 LIM domain only 3 (rhombotin-like 2) -2.12301
IFNA21 interferon, alpha 21 -2.12141
PRRG3 proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane) -2.1198
PGLYRP4 peptidoglycan recognition protein 4 -2.11538
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae) -2.11474
CA6 carbonic anhydrase VI -2.11029
OR10C1 olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene) -2.10727
BCAM basal cell adhesion molecule (Lutheran blood group) -2.10564
GFRA4 GDNF family receptor alpha 4 -2.10466
ACKR2 atypical chemokine receptor 2 -2.10348
SCN3A sodium channel, voltage gated, type III alpha subunit -2.10131
SP140 SP140 nuclear body protein -2.09717
CHRM5 cholinergic receptor, muscarinic 5 -2.09419
PSG3 pregnancy specific beta-1-glycoprotein 3 -2.09071
GPR52 G protein-coupled receptor 52 -2.0892
AMHR2 anti-Mullerian hormone receptor, type II -2.08682
GJB4 gap junction protein, beta 4, 30.3kDa -2.0864
PSG6 pregnancy specific beta-1-glycoprotein 6 -2.07941
RFPL2 ret finger protein-like 2 -2.07815
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 -2.07669
HAVCR1 hepatitis A virus cellular receptor 1 -2.07487
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 -2.0711
HMOX2 heme oxygenase 2 -2.06643
LCE2B late cornified envelope 2B -2.06302
FPGT-TNNI3K FPGT-TNNI3K readthrough -2.06166
ST7L suppression of tumorigenicity 7 like -2.05949
HOXB1 homeobox B1 -2.05506
KRT12 keratin 12, type I -2.05072
BICC1 BicC family RNA binding protein 1 -2.05054
IL22RA1 interleukin 22 receptor, alpha 1 -2.05009
N4BP3 NEDD4 binding protein 3 -2.04604
RXRG retinoid X receptor, gamma -2.04251
PTPN9 protein tyrosine phosphatase, non-receptor type 9 -2.04229
ERN1 endoplasmic reticulum to nucleus signaling 1 -2.03979
ZFP91 ZFP91 zinc finger protein -2.03891
GUCY2D guanylate cyclase 2D, membrane (retina-specific) -2.03885
FRAS1 Fraser extracellular matrix complex subunit 1 -2.03197
NIPAL2 NIPA-like domain containing 2 -2.03171
GREB1L growth regulation by estrogen in breast cancer-like -2.03058
KLHL11 kelch-like family member 11 -2.02995
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 -2.02828
ZNF492 zinc finger protein 492 -2.02794
ZMYM3 zinc finger, MYM-type 3 -2.02547
SHOX short stature homeobox -2.02438
SCNN1D sodium channel, non voltage gated 1 delta subunit -2.02293
GRIK3 glutamate receptor, ionotropic, kainate 3 -2.01978
DRP2 dystrophin related protein 2 -2.01884
CAPN15 calpain 15 -2.01758
BPHL biphenyl hydrolase-like (serine hydrolase) -2.01723
GPR3 G protein-coupled receptor 3 -2.01632
SETDB1 SET domain, bifurcated 1 -2.01367
WDR4 WD repeat domain 4 -2.01345
SH2D3C SH2 domain containing 3C -2.01331
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) -2.01315
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 -2.00935
SCN10A sodium channel, voltage gated, type X alpha subunit -2.0082
RSL1D1 ribosomal L1 domain containing 1 -2.00611
EDA2R ectodysplasin A2 receptor -2.00484
GAST gastrin -2.00457
SLC22A17 solute carrier family 22, member 17 -2.0038
PIGK phosphatidylinositol glycan anchor biosynthesis, class K -2.00157