CRCGN016_MCF10A.WT.HP_24H:J07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description isopropyl-n-(3-chloro?phenyl)carbamate 98.8 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

44 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:J07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
KIF5C kinesin family member 5C 4.38005
AGR2 anterior gradient 2 2.77094
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 2.60514
COMP cartilage oligomeric matrix protein 2.51032
AHSG alpha-2-HS-glycoprotein 2.23618
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 2.09465
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 2.07507
PUS1 pseudouridylate synthase 1 2.05005
MSRA methionine sulfoxide reductase A 2.03231
HPR haptoglobin-related protein 2.02947
ARL6IP4 ADP-ribosylation factor-like 6 interacting protein 4 2.01759
RSBN1 round spermatid basic protein 1 2.00271

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -5.17823
DHRS7 dehydrogenase/reductase (SDR family) member 7 -5.00998
PRPF4 pre-mRNA processing factor 4 -4.88005
LAMB1 laminin, beta 1 -3.36759
VTI1B vesicle transport through interaction with t-SNAREs 1B -3.01999
ARID4B AT rich interactive domain 4B (RBP1-like) -2.91557
ANXA2 annexin A2 -2.83493
GHITM growth hormone inducible transmembrane protein -2.83283
ISOC1 isochorismatase domain containing 1 -2.8038
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -2.7969
BSPRY B-box and SPRY domain containing -2.75538
CTNND1 catenin (cadherin-associated protein), delta 1 -2.72629
PGAM4 phosphoglycerate mutase family member 4 -2.69113
KRT14 keratin 14, type I -2.63638
COG5 component of oligomeric golgi complex 5 -2.59159
ALAD aminolevulinate dehydratase -2.55004
FXYD2 FXYD domain containing ion transport regulator 2 -2.52539
PUF60 poly-U binding splicing factor 60KDa -2.39107
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3 -2.30446
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 -2.27657
TMEM164 transmembrane protein 164 -2.17677
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 -2.14936
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa -2.1205
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -2.11555
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 -2.10441
PAMR1 peptidase domain containing associated with muscle regeneration 1 -2.08674
TEX10 testis expressed 10 -2.04498
BET1 Bet1 golgi vesicular membrane trafficking protein -2.03992
COL21A1 collagen, type XXI, alpha 1 -2.02302
DTD1 D-tyrosyl-tRNA deacylase 1 -2.01874
CREG1 cellular repressor of E1A-stimulated genes 1 -2.00775
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.00606