CRCGN016_MCF10A.WT.HP_24H:J10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dimethylnitrosamine 99.3 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

33 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:J10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 4.12308
AGR2 anterior gradient 2 3.49232
SNAP25 synaptosomal-associated protein, 25kDa 3.46385
OLFML2B olfactomedin-like 2B 3.17376
MSRA methionine sulfoxide reductase A 2.97427
AXIN1 axin 1 2.86395
WIF1 WNT inhibitory factor 1 2.75777
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.72386
HBA1 hemoglobin, alpha 1 2.54358
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.50385
HBB hemoglobin, beta 2.37534
ZMIZ1 zinc finger, MIZ-type containing 1 2.27279
CXCL3 chemokine (C-X-C motif) ligand 3 2.1125
RABL3 RAB, member of RAS oncogene family-like 3 2.0892
LOC112694756 uncharaterized LOC112694756 2.08293

decreased expression

Symbol Name Standardized Value
GDF15 growth differentiation factor 15 -5.68023
TEX10 testis expressed 10 -4.09116
CD58 CD58 molecule -4.00414
NRIP1 nuclear receptor interacting protein 1 -3.8972
NPDC1 neural proliferation, differentiation and control, 1 -3.1077
HMG20B high mobility group 20B -3.10089
MELK maternal embryonic leucine zipper kinase -2.92334
PMM2 phosphomannomutase 2 -2.85666
KIF14 kinesin family member 14 -2.79606
ADI1 acireductone dioxygenase 1 -2.68775
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.68082
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.63389
TENT4A terminal nucleotidyltransferase 4A -2.59276
SQSTM1 sequestosome 1 -2.38462
DMRT1 doublesex and mab-3 related transcription factor 1 -2.21267
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -2.14548
CANT1 calcium activated nucleotidase 1 -2.09898
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2 -2.05096