CRCGN016_MCF10A.WT.HP_24H:J21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description nitrobenzene 11.42 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:J21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
COMP cartilage oligomeric matrix protein 6.60392
PEX11A peroxisomal biogenesis factor 11 alpha 5.16383
E2F2 E2F transcription factor 2 4.41512
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.1954
KIF5C kinesin family member 5C 3.99947
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.86438
RPP38 ribonuclease P/MRP 38kDa subunit 3.14712
RAI14 retinoic acid induced 14 3.02461
CNRIP1 cannabinoid receptor interacting protein 1 2.61426
OLFML2B olfactomedin-like 2B 2.58915
DMTF1 cyclin D binding myb-like transcription factor 1 2.39746
HOOK1 hook microtubule-tethering protein 1 2.32207
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.28072
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.11414
FAM171A1 family with sequence similarity 171, member A1 2.08584
CHAD chondroadherin 2.06795
PARN poly(A)-specific ribonuclease 2.0652
ACAA1 acetyl-CoA acyltransferase 1 2.05459
LYN LYN proto-oncogene, Src family tyrosine kinase 2.04888
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 2.02424
CPPED1 calcineurin-like phosphoesterase domain containing 1 2.00972

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -9.36772
HSPA8 heat shock 70kDa protein 8 -4.90992
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.85989
TNIP1 TNFAIP3 interacting protein 1 -4.51313
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.40632
EXOSC4 exosome component 4 -4.33672
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -3.8977
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -3.61831
MFSD12 major facilitator superfamily domain containing 12 -2.69996
KRT14 keratin 14, type I -2.65947
BTBD3 BTB (POZ) domain containing 3 -2.52219
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 -2.44059
MGLL monoglyceride lipase -2.39145
SGK1 serum/glucocorticoid regulated kinase 1 -2.31407
GDF15 growth differentiation factor 15 -2.29383
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI -2.16765
CACTIN cactin, spliceosome C complex subunit -2.14717
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.14712
FOXF2 forkhead box F2 -2.11316
TENT4A terminal nucleotidyltransferase 4A -2.09994
CCL22 chemokine (C-C motif) ligand 22 -2.07925