CRCGN016_MCF10A.WT.HP_24H:J23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description pyrazinamide 33.32 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

43 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:J23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 3.66339
LSR lipolysis stimulated lipoprotein receptor 3.23083
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 3.14729
SMIM40 small integral membrane protein 40 2.91143
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.88656
ZNF134 zinc finger protein 134 2.84785
BZW2 basic leucine zipper and W2 domains 2 2.68265
SQOR sulfide quinone oxidoreductase 2.6814
ZNF587 zinc finger protein 587 2.68138
ZIM3 zinc finger, imprinted 3 2.59667
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.59021
ZBTB35 zinc finger and BTB domain containing 35 2.58981
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa 2.53561
ZNF551 zinc finger protein 551 2.51465
ZNF8 zinc finger protein 8 2.41574
TMEM50B transmembrane protein 50B 2.39608
LOC128031832 uncharacterized LOC128031832 2.27501
NUCB2 nucleobindin 2 2.24024
SLC30A9 solute carrier family 30 (zinc transporter), member 9 2.1894
SLC75A1 solute carrier family 75 member 1 2.13601
BEX3 brain expressed X-linked 3 2.12672
PCBP4 poly(rC) binding protein 4 2.10829
POLR3B polymerase (RNA) III (DNA directed) polypeptide B 2.088
HOXA10 homeobox A10 2.03436
ZNF606 zinc finger protein 606 2.00043

decreased expression

Symbol Name Standardized Value
UFM1 ubiquitin-fold modifier 1 -9.07153
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.71642
MAPK13 mitogen-activated protein kinase 13 -4.57333
PCNA proliferating cell nuclear antigen -4.42419
GDF15 growth differentiation factor 15 -4.25812
PMM2 phosphomannomutase 2 -3.9722
STXBP2 syntaxin binding protein 2 -3.86273
BAG3 BCL2-associated athanogene 3 -3.6801
TIMP1 TIMP metallopeptidase inhibitor 1 -3.51847
BID BH3 interacting domain death agonist -3.15451
TRIB3 tribbles pseudokinase 3 -3.04923
IFITM1 interferon induced transmembrane protein 1 -2.2302
TMEM230 transmembrane protein 230 -2.18919
MMD monocyte to macrophage differentiation-associated -2.18462
STAT1 signal transducer and activator of transcription 1, 91kDa -2.14625
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.08947
TREM1 triggering receptor expressed on myeloid cells 1 -2.06922
AKAP11 A kinase (PRKA) anchor protein 11 -2.02848