CRCGN016_MCF10A.WT.HP_24H:J24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description pyrazinamide 11.11 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

61 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:J24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 5.33307
AKT1 v-akt murine thymoma viral oncogene homolog 1 5.01011
COMP cartilage oligomeric matrix protein 4.86296
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 4.77129
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.74795
WIF1 WNT inhibitory factor 1 4.69739
CRELD2 cysteine-rich with EGF-like domains 2 3.81552
PDIA5 protein disulfide isomerase family A, member 5 3.32405
BACE2 beta-site APP-cleaving enzyme 2 3.26515
CADM1 cell adhesion molecule 1 2.99819
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 2.70198
ALG12 ALG12, alpha-1,6-mannosyltransferase 2.51816
EPHB2 EPH receptor B2 2.51652
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.47024
SATB1 SATB homeobox 1 2.44732
CDK20 cyclin-dependent kinase 20 2.44504
RTL10 retrotransposon Gag like 10 2.29662
MAN1B1 mannosidase, alpha, class 1B, member 1 2.26112
CLBA1 clathrin binding box of aftiphilin containing 1 2.2249
ATP13A2 ATPase type 13A2 2.22155
HBB hemoglobin, beta 2.21659
ACAA1 acetyl-CoA acyltransferase 1 2.18623
NOSIP nitric oxide synthase interacting protein 2.14609
NAT10 N-acetyltransferase 10 (GCN5-related) 2.039
INS insulin 2.01523

decreased expression

Symbol Name Standardized Value
HACD3 3-hydroxyacyl-CoA dehydratase 3 -5.34653
NVL nuclear VCP-like -5.06291
ACOT9 acyl-CoA thioesterase 9 -4.86717
NLRP4 NLR family, pyrin domain containing 4 -4.80648
STXBP2 syntaxin binding protein 2 -4.63119
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -4.57954
HMG20B high mobility group 20B -4.37965
COG2 component of oligomeric golgi complex 2 -4.36861
PCNA proliferating cell nuclear antigen -3.21303
LUC7L LUC7-like (S. cerevisiae) -2.91066
DEGS1 delta(4)-desaturase, sphingolipid 1 -2.89736
SPG11 spastic paraplegia 11 (autosomal recessive) -2.67637
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.64309
FBXO28 F-box protein 28 -2.54386
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.35261
WDR6 WD repeat domain 6 -2.29399
TTC13 tetratricopeptide repeat domain 13 -2.29275
CNIH4 cornichon family AMPA receptor auxiliary protein 4 -2.2614
TIPIN TIMELESS interacting protein -2.25759
TOE1 target of EGR1, member 1 (nuclear) -2.25304
NELFE negative elongation factor complex member E -2.24225
GPX4 glutathione peroxidase 4 -2.18427
RAB9A RAB9A, member RAS oncogene family -2.16745
RAP2C RAP2C, member of RAS oncogene family -2.15997
CDC42SE1 CDC42 small effector 1 -2.10151
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae) -2.07269
TRIB3 tribbles pseudokinase 3 -2.05367
CRYZL1 crystallin, zeta (quinone reductase)-like 1 -2.04577
VAMP3 vesicle-associated membrane protein 3 -2.04159
FAM50A family with sequence similarity 50, member A -2.02317
XPO7 exportin 7 -2.02167
WDR26 WD repeat domain 26 -2.02104
RHOC ras homolog family member C -2.01746
INTS12 integrator complex subunit 12 -2.01484
CD58 CD58 molecule -2.00691
DPP8 dipeptidyl-peptidase 8 -2.00116