CRCGN016_MCF10A.WT.HP_24H:K12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description wortmannin 1.11 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

89 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:K12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCDC92 coiled-coil domain containing 92 4.30148
ZW10 zw10 kinetochore protein 3.42307
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 3.19649
IGFBP3 insulin-like growth factor binding protein 3 3.15083
VAT1 vesicle amine transport 1 3.03466
STMN2 stathmin 2 3.01904
SPAG4 sperm associated antigen 4 2.92032
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.78325
SNAP25 synaptosomal-associated protein, 25kDa 2.77572
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.6871
LGMN legumain 2.6559
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.61253
GATA3 GATA binding protein 3 2.60437
BLCAP bladder cancer associated protein 2.57351
GFUS GDP-L-fucose synthase 2.5424
ADRB2 adrenoceptor beta 2, surface 2.46802
METRN meteorin, glial cell differentiation regulator 2.43411
TCEAL4 transcription elongation factor A (SII)-like 4 2.42196
KIF5C kinesin family member 5C 2.3989
RBKS ribokinase 2.38522
FHL2 four and a half LIM domains 2 2.37812
STK25 serine/threonine kinase 25 2.29843
SCCPDH saccharopine dehydrogenase (putative) 2.28283
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.27283
INA internexin neuronal intermediate filament protein, alpha 2.27074
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2 2.24358
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 2.22299
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.21429
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 2.1913
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.15816
FUZ fuzzy planar cell polarity protein 2.12845
TSPAN4 tetraspanin 4 2.10741
GAA glucosidase, alpha; acid 2.10331
NSG2 neuronal vesicle trafficking associated 2 2.04364
RALGDS ral guanine nucleotide dissociation stimulator 2.03249
TUBB6 tubulin, beta 6 class V 2.02891

decreased expression

Symbol Name Standardized Value
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -5.7661
GDF15 growth differentiation factor 15 -5.74013
CDC20 cell division cycle 20 -4.54657
ARID4B AT rich interactive domain 4B (RBP1-like) -4.08554
HAT1 histone acetyltransferase 1 -3.93942
KIF20A kinesin family member 20A -3.67342
CDPF1 cysteine-rich, DPF motif domain containing 1 -3.37542
ISOC1 isochorismatase domain containing 1 -3.35727
GTF2A2 general transcription factor IIA, 2, 12kDa -3.34535
CD320 CD320 molecule -3.32219
CCNB2 cyclin B2 -3.2367
CCNB1 cyclin B1 -3.03233
SMNDC1 survival motor neuron domain containing 1 -2.94071
MRPS7 mitochondrial ribosomal protein S7 -2.90556
NUP85 nucleoporin 85kDa -2.83715
LBR lamin B receptor -2.79577
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.76201
DDIT4 DNA-damage-inducible transcript 4 -2.74212
HMG20B high mobility group 20B -2.74041
NLRP2B NLR family pyrin domain containing 2B -2.72902
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.71864
DEPDC1 DEP domain containing 1 -2.66086
CCNA2 cyclin A2 -2.63883
PLK1 polo-like kinase 1 -2.5697
KIF14 kinesin family member 14 -2.51475
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.46035
BHLHE40 basic helix-loop-helix family, member e40 -2.43462
NEK2 NIMA-related kinase 2 -2.407
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 -2.40071
BIRC5 baculoviral IAP repeat containing 5 -2.38994
CCNH cyclin H -2.35645
MFN1 mitofusin 1 -2.30322
GOLT1B golgi transport 1B -2.27067
TLK2 tousled-like kinase 2 -2.25393
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 -2.22824
CENPC centromere protein C -2.19778
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast) -2.19512
MARCHF5 membrane associated ring-CH-type finger 5 -2.1804
VBP1 von Hippel-Lindau binding protein 1 -2.18
AARS1 alanyl-tRNA synthetase 1 -2.15931
MRPL58 mitochondrial ribosomal protein L58 -2.14961
SAP30BP SAP30 binding protein -2.14693
AURKB aurora kinase B -2.09293
RPA3 replication protein A3, 14kDa -2.0878
SUMO4 small ubiquitin-like modifier 4 -2.062
RPL39L ribosomal protein L39-like -2.06187
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.06032
CDK1 cyclin-dependent kinase 1 -2.0282
ADI1 acireductone dioxygenase 1 -2.02574
MPC2 mitochondrial pyruvate carrier 2 -2.02334
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 -2.02248
MTFR1 mitochondrial fission regulator 1 -2.01265
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2 -2.00191