CRCGN016_MCF10A.WT.HP_24H:K13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,2-dibromo-3-chloropropane 99.3 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

40 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:K13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MMP1 matrix metallopeptidase 1 4.6989
WASF3 WAS protein family, member 3 3.84802
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.67582
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 3.66917
AGR2 anterior gradient 2 3.15659
BACE2 beta-site APP-cleaving enzyme 2 3.13757
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.24788
PDIA5 protein disulfide isomerase family A, member 5 2.18836
RPP40 ribonuclease P/MRP 40kDa subunit 2.17925
DMAC2L distal membrane arm assembly component 2 like 2.17067
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.15893
TBXA2R thromboxane A2 receptor 2.04626
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.01333

decreased expression

Symbol Name Standardized Value
PRPF4 pre-mRNA processing factor 4 -5.32067
BASP1 brain abundant, membrane attached signal protein 1 -4.94189
KRT14 keratin 14, type I -4.50471
OXA1L oxidase (cytochrome c) assembly 1-like -4.39378
TEX10 testis expressed 10 -4.36243
TOPBP1 topoisomerase (DNA) II binding protein 1 -4.28989
SGK1 serum/glucocorticoid regulated kinase 1 -2.87264
GDF15 growth differentiation factor 15 -2.86518
CDK5RAP2 CDK5 regulatory subunit associated protein 2 -2.78446
FAIM Fas apoptotic inhibitory molecule -2.6633
ACAA1 acetyl-CoA acyltransferase 1 -2.57668
DUSP6 dual specificity phosphatase 6 -2.50553
FKBP15 FK506 binding protein 15, 133kDa -2.46915
ANXA2 annexin A2 -2.46749
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.36993
DRC4 dynein regulatory complex subunit 4 -2.36329
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -2.35067
ARID4B AT rich interactive domain 4B (RBP1-like) -2.26916
BSPRY B-box and SPRY domain containing -2.1876
ALAD aminolevulinate dehydratase -2.16872
MAP6D1 MAP6 domain containing 1 -2.07471
RNF31 ring finger protein 31 -2.07409
DEF6 differentially expressed in FDCP 6 homolog (mouse) -2.07271
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3 -2.07074
SLC31A2 solute carrier family 31 (copper transporter), member 2 -2.06408
CCNDBP1 cyclin D-type binding-protein 1 -2.03647
SLC31A1 solute carrier family 31 (copper transporter), member 1 -2.02401