CRCGN016_MCF10A.WT.HP_24H:K16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description acetaldehyde 103.79 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

53 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:K16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SNAP25 synaptosomal-associated protein, 25kDa 7.86662
AGR2 anterior gradient 2 5.99343
WIF1 WNT inhibitory factor 1 5.91906
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 5.29253
CXCL2 chemokine (C-X-C motif) ligand 2 4.66699
STMN2 stathmin 2 3.47157
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 3.38296
CDK19 cyclin-dependent kinase 19 3.09969
SV2B synaptic vesicle glycoprotein 2B 2.99875
NSG2 neuronal vesicle trafficking associated 2 2.95918
NEFL neurofilament, light polypeptide 2.86349
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 2.80562
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 2.791
RPH3A rabphilin 3A 2.77582
SNAP91 synaptosomal-associated protein, 91kDa 2.76811
SYN1 synapsin I 2.75469
RGS7 regulator of G-protein signaling 7 2.75189
LGI1 leucine-rich, glioma inactivated 1 2.72082
SCG3 secretogranin III 2.7004
TAC1 tachykinin, precursor 1 2.48108
TSEN2 TSEN2 tRNA splicing endonuclease subunit 2.46105
VSNL1 visinin-like 1 2.4514
SH3GL2 SH3-domain GRB2-like 2 2.41275
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 2.38945
RGS20 regulator of G-protein signaling 20 2.36024
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.3527
FRRS1L ferric-chelate reductase 1-like 2.34695
PDYN prodynorphin 2.31617
NRXN1 neurexin 1 2.3119
NEFM neurofilament, medium polypeptide 2.31085
MYT1L myelin transcription factor 1-like 2.25598
PCSK1 proprotein convertase subtilisin/kexin type 1 2.19534
CDH18 cadherin 18, type 2 2.19325
CXCL3 chemokine (C-X-C motif) ligand 3 2.15417
GNG3 guanine nucleotide binding protein (G protein), gamma 3 2.13911
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 2.12061
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.10157
SNCB synuclein, beta 2.09614
CDH10 cadherin 10, type 2 (T2-cadherin) 2.08647
PCSK2 proprotein convertase subtilisin/kexin type 2 2.08455
OLFM1 olfactomedin 1 2.07649
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 2.07582
ZBTB35 zinc finger and BTB domain containing 35 2.06602
LRRN3 leucine rich repeat neuronal 3 2.06332
GPKOW G patch domain and KOW motifs 2.04935
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 2.01531
MKKS McKusick-Kaufman syndrome 2.00133

decreased expression

Symbol Name Standardized Value
GDF15 growth differentiation factor 15 -3.83229
SGK1 serum/glucocorticoid regulated kinase 1 -3.36231
TES testin LIM domain protein -2.63455
OXA1L oxidase (cytochrome c) assembly 1-like -2.33847
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -2.23001
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.09889