CRCGN016_MCF10A.WT.HP_24H:K22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description furosemide 97.78 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

28 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:K22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAMLD1 mastermind-like domain containing 1 5.6788
SPAG4 sperm associated antigen 4 4.18361
MAST2 microtubule associated serine/threonine kinase 2 4.05103
IGHMBP2 immunoglobulin mu binding protein 2 3.50296
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.87313
ELANE elastase, neutrophil expressed 2.68442
ACAA1 acetyl-CoA acyltransferase 1 2.61249
RTN2 reticulon 2 2.45637
RANBP17 RAN binding protein 17 2.44688
MROH7 maestro heat-like repeat family member 7 2.37386
BPI bactericidal/permeability-increasing protein 2.24905
NMRK1 nicotinamide riboside kinase 1 2.24161
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.15333
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) 2.142
PRTN3 proteinase 3 2.12217
ADAM30 ADAM metallopeptidase domain 30 2.09139
UNC13D unc-13 homolog D (C. elegans) 2.05746
TENT5C terminal nucleotidyltransferase 5C 2.01143

decreased expression

Symbol Name Standardized Value
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -4.67332
GDF15 growth differentiation factor 15 -4.53097
PMM2 phosphomannomutase 2 -4.43131
HOXA5 homeobox A5 -3.36646
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -2.87606
MTERF3 mitochondrial transcription termination factor 3 -2.66493
NGRN neugrin, neurite outgrowth associated -2.56869
XPO7 exportin 7 -2.08654
ATG3 autophagy related 3 -2.07584
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -2.02108