CRCGN016_MCF10A.WT.HP_24H:K23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description furosemide 32.59 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

23 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:K23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGR2 anterior gradient 2 5.3445
ACAA1 acetyl-CoA acyltransferase 1 3.8588
CHEK1 checkpoint kinase 1 3.39103
TSEN2 TSEN2 tRNA splicing endonuclease subunit 2.7286
TBX2 T-box 2 2.65132
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.64377
E2F2 E2F transcription factor 2 2.54996
TSPAN6 tetraspanin 6 2.51624
SH3YL1 SH3 and SYLF domain containing 1 2.10692
CAPN1 calpain 1, (mu/I) large subunit 2.0961

decreased expression

Symbol Name Standardized Value
DERA deoxyribose-phosphate aldolase (putative) -4.02095
GTPBP8 GTP-binding protein 8 (putative) -3.97875
TXNDC9 thioredoxin domain containing 9 -2.9681
MSMO1 methylsterol monooxygenase 1 -2.71153
SGK1 serum/glucocorticoid regulated kinase 1 -2.55701
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.50068
PGAM4 phosphoglycerate mutase family member 4 -2.34993
KDM3A lysine (K)-specific demethylase 3A -2.29775
NRIP1 nuclear receptor interacting protein 1 -2.17486
SEZ6L seizure related 6 homolog (mouse)-like -2.14668
RAB32 RAB32, member RAS oncogene family -2.14481
GDF15 growth differentiation factor 15 -2.07218
RALGDS ral guanine nucleotide dissociation stimulator -2.01433