CRCGN016_MCF10A.WT.HP_24H:L02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sorbic-acid 33.1 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

60 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:L02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.9659
TLR4 toll-like receptor 4 4.82545
EML3 echinoderm microtubule associated protein like 3 4.82376
EPHB2 EPH receptor B2 4.77951
WFS1 Wolfram syndrome 1 (wolframin) 4.38197
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 3.39822
COMP cartilage oligomeric matrix protein 3.23728
TPD52L2 tumor protein D52-like 2 3.21455
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 3.03858
AXIN1 axin 1 2.98196
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.92895
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.92662
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.55957
H2BC12 H2B clustered histone 12 2.55166
AOAH acyloxyacyl hydrolase (neutrophil) 2.5371
C5AR1 complement component 5a receptor 1 2.48979
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) 2.4842
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.41445
CENPT centromere protein T 2.40872
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 2.40635
TLR8 toll-like receptor 8 2.26847
FPR2 formyl peptide receptor 2 2.21382
CLEC7A C-type lectin domain family 7, member A 2.19942
TNFSF12-TNFSF13 TNFSF12-TNFSF13 readthrough 2.16969
PCCA propionyl CoA carboxylase, alpha polypeptide 2.15022
CCR1 chemokine (C-C motif) receptor 1 2.09625
TBXAS1 thromboxane A synthase 1 (platelet) 2.08375
XAF1 XIAP associated factor 1 2.07553
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.06291
MARCHF1 membrane associated ring-CH-type finger 1 2.05486
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) 2.04954
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 2.03021
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase 2.00474
MTARC1 mitochondrial amidoxime reducing component 1 2.00167
CYBB cytochrome b-245, beta polypeptide 2.00106

decreased expression

Symbol Name Standardized Value
ENOPH1 enolase-phosphatase 1 -5.56962
BAG3 BCL2-associated athanogene 3 -4.93601
ANXA2 annexin A2 -4.64588
COG7 component of oligomeric golgi complex 7 -4.39826
SCYL3 SCY1-like 3 (S. cerevisiae) -4.09509
S100A4 S100 calcium binding protein A4 -3.85738
CANT1 calcium activated nucleotidase 1 -3.82049
BPHL biphenyl hydrolase-like (serine hydrolase) -3.30557
NGRN neugrin, neurite outgrowth associated -2.72
ARID4B AT rich interactive domain 4B (RBP1-like) -2.62821
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.60618
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type -2.48497
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.42115
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) -2.3997
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.34332
HTRA1 HtrA serine peptidase 1 -2.3381
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 -2.22334
HSPA1A heat shock 70kDa protein 1A -2.09492
NEFH neurofilament, heavy polypeptide -2.09228
BCL9 B-cell CLL/lymphoma 9 -2.07583
TM4SF4 transmembrane 4 L six family member 4 -2.06082
QRICH1 glutamine-rich 1 -2.0371
TIMP1 TIMP metallopeptidase inhibitor 1 -2.02119
CCDC68 coiled-coil domain containing 68 -2.0124
CERS2 ceramide synthase 2 -2.00469