CRCGN016_MCF10A.WT.HP_24H:L04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hydrazine sulfate 99.8 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:L04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DNM1 dynamin 1 3.52577
CNPY3 canopy FGF signaling regulator 3 3.45483
ABHD4 abhydrolase domain containing 4 3.2549
HLA-DMA major histocompatibility complex, class II, DM alpha 2.99653
MAMLD1 mastermind-like domain containing 1 2.759
E2F2 E2F transcription factor 2 2.70813
CCL2 chemokine (C-C motif) ligand 2 2.68943
EML3 echinoderm microtubule associated protein like 3 2.68115
SNAP25 synaptosomal-associated protein, 25kDa 2.62428
STMN2 stathmin 2 2.48015
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.43997
CCNF cyclin F 2.37738
FRS2 fibroblast growth factor receptor substrate 2 2.30923
NSG2 neuronal vesicle trafficking associated 2 2.28277
PRUNE1 prune exopolyphosphatase 1 2.20699
COMP cartilage oligomeric matrix protein 2.1687
GDF2 growth differentiation factor 2 2.1686
A4GALT alpha 1,4-galactosyltransferase 2.13887
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.0904
TP53BP2 tumor protein p53 binding protein 2 2.062
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 2.04363
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 2.02463

decreased expression

Symbol Name Standardized Value
SLC35F2 solute carrier family 35, member F2 -4.39613
PRPF4 pre-mRNA processing factor 4 -3.55327
TXNDC9 thioredoxin domain containing 9 -3.45988
ANXA2 annexin A2 -3.3144
ENOPH1 enolase-phosphatase 1 -3.20077
CDC45 cell division cycle 45 -3.09417
PDCL3 phosducin-like 3 -2.9862
VDAC1 voltage-dependent anion channel 1 -2.74162
SORBS3 sorbin and SH3 domain containing 3 -2.67408
BASP1 brain abundant, membrane attached signal protein 1 -2.65323
HMG20B high mobility group 20B -2.5913
ARID4B AT rich interactive domain 4B (RBP1-like) -2.5069
TMEM131 transmembrane protein 131 -2.376
SGK1 serum/glucocorticoid regulated kinase 1 -2.1951
LMAN2L lectin, mannose-binding 2-like -2.17327
BAD BCL2-associated agonist of cell death -2.16725
EIF5B eukaryotic translation initiation factor 5B -2.16202
RXYLT1 ribitol xylosyltransferase 1 -2.1151
FANCF Fanconi anemia, complementation group F -2.11113
FGD6 FYVE, RhoGEF and PH domain containing 6 -2.0019