CRCGN016_MCF10A.WT.HP_24H:L05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hydrazine sulfate 33.27 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

55 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:L05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PNKP polynucleotide kinase 3'-phosphatase 4.99655
ARID5B AT rich interactive domain 5B (MRF1-like) 4.66322
PRKCH protein kinase C, eta 4.50825
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 3.7023
NCK2 NCK adaptor protein 2 3.58733
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 3.35219
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.91462
AGR2 anterior gradient 2 2.63011
HBB hemoglobin, beta 2.53209
GOLGA7 golgin A7 2.32032
TSPAN31 tetraspanin 31 2.24619
PLTP phospholipid transfer protein 2.17481
LYN LYN proto-oncogene, Src family tyrosine kinase 2.16983
AP3M2 adaptor-related protein complex 3, mu 2 subunit 2.14156
ABHD11 abhydrolase domain containing 11 2.10417
GLDC glycine dehydrogenase (decarboxylating) 2.10417
CD2 CD2 molecule 2.09736
ERCC2 excision repair cross-complementation group 2 2.07698
AHCY adenosylhomocysteinase 2.06313
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 2.05722
LSM1 LSM1, U6 small nuclear RNA associated 2.05472
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa 2.05382
PTOV1 prostate tumor overexpressed 1 2.05348
TLCD3A TLC domain containing 3A 2.02948

decreased expression

Symbol Name Standardized Value
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -5.69874
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -5.12591
BASP1 brain abundant, membrane attached signal protein 1 -4.95442
KIF20A kinesin family member 20A -4.77967
CDC45 cell division cycle 45 -4.52121
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -4.3627
OXA1L oxidase (cytochrome c) assembly 1-like -4.25662
SGK1 serum/glucocorticoid regulated kinase 1 -3.67507
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 -2.88018
TENT4A terminal nucleotidyltransferase 4A -2.87284
ARID4B AT rich interactive domain 4B (RBP1-like) -2.75254
AURKB aurora kinase B -2.73454
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 -2.59685
PSENEN presenilin enhancer gamma secretase subunit -2.47577
WDR62 WD repeat domain 62 -2.46078
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 -2.43969
METTL17 methyltransferase like 17 -2.40066
MXD3 MAX dimerization protein 3 -2.29799
TUBA4B tubulin, alpha 4b -2.26553
USP3 ubiquitin specific peptidase 3 -2.21729
FGF4 fibroblast growth factor 4 -2.17338
GSK3A glycogen synthase kinase 3 alpha -2.1374
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.10892
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon -2.10779
GADD45B growth arrest and DNA-damage-inducible, beta -2.05776
ETFB electron-transfer-flavoprotein, beta polypeptide -2.04958
SHBG sex hormone-binding globulin -2.04704
FKBP4 FK506 binding protein 4, 59kDa -2.03368
CNTFR ciliary neurotrophic factor receptor -2.02934
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa -2.02308
ADRA2B adrenoceptor alpha 2B -2.01401