CRCGN016_MCF10A.WT.HP_24H:L08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description fd & c blue no. 2 33.27 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

41 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:L08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGR2 anterior gradient 2 3.91833
ACAA1 acetyl-CoA acyltransferase 1 3.91829
COMP cartilage oligomeric matrix protein 3.83676
TBX2 T-box 2 3.66028
CNRIP1 cannabinoid receptor interacting protein 1 3.32127
E2F2 E2F transcription factor 2 3.25291
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.9904
CEP192 centrosomal protein 192kDa 2.59779
MARCO macrophage receptor with collagenous structure 2.31503
CTRB1 chymotrypsinogen B1 2.31
PLA2G2D phospholipase A2, group IID 2.22162
OLFML2B olfactomedin-like 2B 2.04849
DCTN3 dynactin 3 (p22) 2.00872

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -9.9505
CANT1 calcium activated nucleotidase 1 -4.22382
CDC25B cell division cycle 25B -3.65668
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.52592
SGK1 serum/glucocorticoid regulated kinase 1 -3.38326
GDF15 growth differentiation factor 15 -3.18524
KRT14 keratin 14, type I -3.13687
GPX4 glutathione peroxidase 4 -2.92312
TRAPPC3 trafficking protein particle complex 3 -2.87948
MFSD12 major facilitator superfamily domain containing 12 -2.86
MAP2K2 mitogen-activated protein kinase kinase 2 -2.76026
PARP2 poly (ADP-ribose) polymerase 2 -2.67759
NT5DC2 5'-nucleotidase domain containing 2 -2.6111
SALL1 spalt-like transcription factor 1 -2.3296
MAP7D1 MAP7 domain containing 1 -2.30352
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3 -2.27993
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma -2.27845
FAM174C family with sequence similarity 174 member C -2.25285
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B -2.23854
RBM34 RNA binding motif protein 34 -2.18614
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.18029
MSN moesin -2.14044
CEP112 centrosomal protein 112kDa -2.13443
ZNF302 zinc finger protein 302 -2.09992
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent -2.09295
GGPS1 geranylgeranyl diphosphate synthase 1 -2.03391
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1 -2.0271
CACTIN cactin, spliceosome C complex subunit -2.01294