CRCGN016_MCF10A.WT.HP_24H:L12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description disulfiram 11.09 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

22 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:L12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
KLHL21 kelch-like family member 21 4.46363
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.35341
UGDH UDP-glucose 6-dehydrogenase 4.17445
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 3.59736
CGRRF1 cell growth regulator with ring finger domain 1 2.48629
BMP4 bone morphogenetic protein 4 2.45814
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 2.20254
SATB1 SATB homeobox 1 2.15425
PDIA5 protein disulfide isomerase family A, member 5 2.13177

decreased expression

Symbol Name Standardized Value
S100A8 S100 calcium binding protein A8 -4.75934
FPGS folylpolyglutamate synthase -3.34728
RBM34 RNA binding motif protein 34 -3.04487
TRAP1 TNF receptor-associated protein 1 -2.90543
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.75431
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.60311
MYLK3 myosin light chain kinase 3 -2.18843
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 -2.12512
ZNF528 zinc finger protein 528 -2.08145
RAMP2 receptor (G protein-coupled) activity modifying protein 2 -2.05788
DLX6 distal-less homeobox 6 -2.05026
ZNF480 zinc finger protein 480 -2.04697
FAIM Fas apoptotic inhibitory molecule -2.0002