CRCGN016_MCF10A.WT.HP_24H:L13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,2,3-trichloropropane 100.3 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

39 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:L13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STAP2 signal transducing adaptor family member 2 4.36315
CLNS1A chloride channel, nucleotide-sensitive, 1A 3.83617
RSF1 remodeling and spacing factor 1 3.38306
AAMDC adipogenesis associated, Mth938 domain containing 2.91212
ALG8 ALG8, alpha-1,3-glucosyltransferase 2.88289
EMSY EMSY transcriptional repressor, BRCA2 interacting 2.82613
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 2.5149
THAP12 THAP domain containing 12 2.47338
SESN1 sestrin 1 2.4168
EPN2 epsin 2 2.31613
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.28191
UVRAG UV radiation resistance associated 2.2143
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta 2.17623
SPAG5 sperm associated antigen 5 2.145
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.14131
CNIH3 cornichon family AMPA receptor auxiliary protein 3 2.13334
EAPP E2F-associated phosphoprotein 2.10054
SOX13 SRY (sex determining region Y)-box 13 2.04392

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -5.29363
DSG2 desmoglein 2 -4.67175
CAB39 calcium binding protein 39 -4.63795
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.48576
KRT14 keratin 14, type I -4.16419
PCNA proliferating cell nuclear antigen -4.04681
MTERF3 mitochondrial transcription termination factor 3 -3.95649
HEATR1 HEAT repeat containing 1 -3.4394
CLTB clathrin, light chain B -3.42253
CANT1 calcium activated nucleotidase 1 -2.68872
AP5S1 adaptor-related protein complex 5, sigma 1 subunit -2.30868
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -2.25203
DIO3 deiodinase, iodothyronine, type III -2.23022
INSM1 insulinoma-associated 1 -2.16911
KRT31 keratin 31, type I -2.11783
CSTA cystatin A (stefin A) -2.09549
AMHR2 anti-Mullerian hormone receptor, type II -2.06021
RELN reelin -2.05401
PRELP proline/arginine-rich end leucine-rich repeat protein -2.04018
SNRPB2 small nuclear ribonucleoprotein polypeptide B -2.02802
ZNF671 zinc finger protein 671 -2.01042