CRCGN016_MCF10A.WT.HP_24H:L14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,2,3-trichloropropane 33.43 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

31 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:L14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GPER1 G protein-coupled estrogen receptor 1 5.01011
SPAG4 sperm associated antigen 4 4.88474
ABHD4 abhydrolase domain containing 4 4.61815
AGR2 anterior gradient 2 4.40525
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 4.05781
KDM5A lysine (K)-specific demethylase 5A 3.03699
DENND2D DENN/MADD domain containing 2D 2.86052
ACAA1 acetyl-CoA acyltransferase 1 2.59816
COMP cartilage oligomeric matrix protein 2.50193
SATB1 SATB homeobox 1 2.3882
TM9SF3 transmembrane 9 superfamily member 3 2.17283
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9 2.13174
FKBP11 FK506 binding protein 11, 19 kDa 2.10161
WIF1 WNT inhibitory factor 1 2.09897
TXNL4B thioredoxin-like 4B 2.09515

decreased expression

Symbol Name Standardized Value
GDF15 growth differentiation factor 15 -5.70161
RNF167 ring finger protein 167 -5.29475
PCCB propionyl CoA carboxylase, beta polypeptide -4.63652
TNIP1 TNFAIP3 interacting protein 1 -3.66903
BASP1 brain abundant, membrane attached signal protein 1 -3.64551
CHIC2 cysteine-rich hydrophobic domain 2 -3.63359
DYNLT3 dynein, light chain, Tctex-type 3 -3.45997
PFN1 profilin 1 -2.48145
KRT14 keratin 14, type I -2.26334
C1QBP complement component 1, q subcomponent binding protein -2.2555
MSN moesin -2.1413
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) -2.10033
MTERF3 mitochondrial transcription termination factor 3 -2.08752
ISOC1 isochorismatase domain containing 1 -2.02953
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.00545
MYH9 myosin, heavy chain 9, non-muscle -2.00435