CRCGN016_MCF10A.WT.HP_24H:L18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,2-dichloropropane 11.03 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

30 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:L18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGR2 anterior gradient 2 4.44996
HBA1 hemoglobin, alpha 1 3.62792
ARID5B AT rich interactive domain 5B (MRF1-like) 3.55231
CXCL2 chemokine (C-X-C motif) ligand 2 3.22065
COMP cartilage oligomeric matrix protein 2.97296
KLHL9 kelch-like family member 9 2.6196
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.49009
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.44277
APOLD1 apolipoprotein L domain containing 1 2.21548
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.16739
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.10972
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 2.06935

decreased expression

Symbol Name Standardized Value
COG2 component of oligomeric golgi complex 2 -3.82748
UFM1 ubiquitin-fold modifier 1 -3.6591
HSPA8 heat shock 70kDa protein 8 -3.57734
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -3.43133
PCCB propionyl CoA carboxylase, beta polypeptide -3.39893
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.20059
CHIC2 cysteine-rich hydrophobic domain 2 -3.12654
PUF60 poly-U binding splicing factor 60KDa -2.98926
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.67797
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.65584
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 -2.49693
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -2.48421
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.43111
ARID4B AT rich interactive domain 4B (RBP1-like) -2.32332
MSMO1 methylsterol monooxygenase 1 -2.22768
SCRIB scribbled planar cell polarity protein -2.20971
C1QBP complement component 1, q subcomponent binding protein -2.07636
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.05466