CRCGN016_MCF10A.WT.HP_24H:L19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description atrazine 99.97 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

196 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:L19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGR2 anterior gradient 2 5.25105
PPARG peroxisome proliferator-activated receptor gamma 4.97619
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.88237
ABHD4 abhydrolase domain containing 4 4.76172
SNAP25 synaptosomal-associated protein, 25kDa 4.52073
MAP7 microtubule-associated protein 7 4.42153
KDM5D lysine (K)-specific demethylase 5D 4.39274
MEF2C myocyte enhancer factor 2C 4.36327
TSEN2 TSEN2 tRNA splicing endonuclease subunit 4.31054
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 4.02042
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled 3.77338
TBX2 T-box 2 3.58489
USP9Y ubiquitin specific peptidase 9, Y-linked 3.50721
MTA2 metastasis associated 1 family, member 2 3.41329
ZFY zinc finger protein, Y-linked 3.28503
MDM4 MDM4, p53 regulator 3.24859
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 3.22041
CNRIP1 cannabinoid receptor interacting protein 1 3.20197
CERK ceramide kinase 3.19395
SYN1 synapsin I 3.14576
DAZ2 deleted in azoospermia 2 3.12017
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 3.10722
CEPT1 choline/ethanolamine phosphotransferase 1 3.00193
TMEM156 transmembrane protein 156 2.96412
SNAP91 synaptosomal-associated protein, 91kDa 2.9622
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 2.96073
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.93991
OLFM1 olfactomedin 1 2.93682
DMTF1 cyclin D binding myb-like transcription factor 1 2.89734
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.81448
POU2F1 POU class 2 homeobox 1 2.78912
ERCC4 excision repair cross-complementation group 4 2.77007
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.75724
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2 2.68145
PTPRT protein tyrosine phosphatase, receptor type, T 2.66077
KLHL11 kelch-like family member 11 2.65049
RBMY1J RNA binding motif protein, Y-linked, family 1, member J 2.6165
RPAIN RPA interacting protein 2.605
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 2.57918
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.57727
SYT1 synaptotagmin I 2.55798
MGAT4C MGAT4 family, member C 2.55588
FSCN3 fascin actin-bundling protein 3, testicular 2.54253
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) 2.53566
SENP7 SUMO1/sentrin specific peptidase 7 2.52416
BAG1 BCL2-associated athanogene 2.49883
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 2.49472
NRCAM neuronal cell adhesion molecule 2.47658
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 2.46594
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 2.46131
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 2.45866
DMAP1 DNA methyltransferase 1 associated protein 1 2.44459
USP2 ubiquitin specific peptidase 2 2.43801
RGS7 regulator of G-protein signaling 7 2.43253
TLR6 toll-like receptor 6 2.41952
KRT20 keratin 20, type I 2.41025
PREB prolactin regulatory element binding 2.36072
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 2.34594
DENND2D DENN/MADD domain containing 2D 2.34507
ACSBG2 acyl-CoA synthetase bubblegum family member 2 2.33426
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 2.33268
SYNPO2L synaptopodin 2-like 2.32312
TAPT1 transmembrane anterior posterior transformation 1 2.32267
GUSB glucuronidase, beta 2.31734
AP1M2 adaptor-related protein complex 1, mu 2 subunit 2.31537
CSAD cysteine sulfinic acid decarboxylase 2.31433
NIPSNAP3B nipsnap homolog 3B (C. elegans) 2.31177
UPK2 uroplakin 2 2.3091
ABHD18 abhydrolase domain containing 18 2.30431
WDR76 WD repeat domain 76 2.29738
SCN3B sodium channel, voltage gated, type III beta subunit 2.2878
CARTPT CART prepropeptide 2.28434
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 2.2801
SCG3 secretogranin III 2.27915
HNRNPL heterogeneous nuclear ribonucleoprotein L 2.27618
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 2.25727
NRXN1 neurexin 1 2.25398
MTHFSD methenyltetrahydrofolate synthetase domain containing 2.24108
THRAP3 thyroid hormone receptor associated protein 3 2.24098
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 2.21967
GSTCD glutathione S-transferase, C-terminal domain containing 2.21488
MMP27 matrix metallopeptidase 27 2.2076
LAMC3 laminin, gamma 3 2.20008
LIMD1 LIM domains containing 1 2.19904
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.19438
ICAM2 intercellular adhesion molecule 2 2.19363
COQ6 coenzyme Q6 monooxygenase 2.19272
SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5 2.19092
SPINT4 serine peptidase inhibitor, Kunitz type 4 2.18985
PHACTR4 phosphatase and actin regulator 4 2.18893
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.18365
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 2.18191
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 2.17647
SMCP sperm mitochondria-associated cysteine-rich protein 2.16495
P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4 2.16424
ENTREP1 endosomal transmembrane epsin interactor 1 2.15296
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 2.15226
KPNA5 karyopherin alpha 5 (importin alpha 6) 2.14192
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 2.13694
MYG1 MYG1 exonuclease 2.13571
PHKG1 phosphorylase kinase, gamma 1 (muscle) 2.13362
ZNF343 zinc finger protein 343 2.13338
CNTN1 contactin 1 2.13126
MAOA monoamine oxidase A 2.13108
STAT2 signal transducer and activator of transcription 2, 113kDa 2.12929
PCDHGA10 protocadherin gamma subfamily A, 10 2.12679
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 2.12463
TULP2 tubby like protein 2 2.12169
GDAP1 ganglioside induced differentiation associated protein 1 2.12019
PGAP4 post-GPI attachment to proteins GalNAc transferase 4 2.11397
OR1D4 olfactory receptor, family 1, subfamily D, member 4 (gene/pseudogene) 2.11298
MMP26 matrix metallopeptidase 26 2.11239
VPS50 VPS50 subunit of EARP/GARPII complex 2.11061
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 2.10938
DCAF10 DDB1 and CUL4 associated factor 10 2.10893
HSPB3 heat shock 27kDa protein 3 2.10334
NOL10 nucleolar protein 10 2.0971
CDH12 cadherin 12, type 2 (N-cadherin 2) 2.09664
EFCC1 EF-hand and coiled-coil domain containing 1 2.08836
ZNF345 zinc finger protein 345 2.08444
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 2.08078
SRSF6 serine/arginine-rich splicing factor 6 2.08019
AQP4 aquaporin 4 2.07633
AHDC1 AT hook, DNA binding motif, containing 1 2.07544
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4 2.07386
TBR1 T-box, brain, 1 2.07201
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 2.06804
ZC3HAV1 zinc finger CCCH-type, antiviral 1 2.06406
DAO D-amino-acid oxidase 2.06327
TAS2R4 taste receptor, type 2, member 4 2.06026
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 2.04335
IL13RA2 interleukin 13 receptor, alpha 2 2.04303
MBTD1 mbt domain containing 1 2.04277
AKR1C3 aldo-keto reductase family 1, member C3 2.04216
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 2.03578
ADAM21 ADAM metallopeptidase domain 21 2.03322
ATP10B ATPase, class V, type 10B 2.0324
HCRT hypocretin (orexin) neuropeptide precursor 2.03207
BMP10 bone morphogenetic protein 10 2.03173
EDDM3B epididymal protein 3B 2.03053
APLNR apelin receptor 2.0301
LGALS13 lectin, galactoside-binding, soluble, 13 2.02825
NUTF2 nuclear transport factor 2 2.01803
SEC31B SEC31 homolog B (S. cerevisiae) 2.01626
CRYGB crystallin, gamma B 2.01319
PRKG1 protein kinase, cGMP-dependent, type I 2.01295
P2RY1 purinergic receptor P2Y, G-protein coupled, 1 2.01197
ATOH1 atonal homolog 1 (Drosophila) 2.01125
DCN decorin 2.01022
INCENP inner centromere protein antigens 135/155kDa 2.00953
CTAGE1 cutaneous T-cell lymphoma-associated antigen 1 2.00751
HMOX1 heme oxygenase 1 2.00726
SH2B2 SH2B adaptor protein 2 2.0052
GNAT3 guanine nucleotide binding protein, alpha transducing 3 2.00476
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 2.0044
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 2.00431
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 2.00233
AMPH amphiphysin 2.00188

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -4.95764
PCNA proliferating cell nuclear antigen -4.86469
KIF14 kinesin family member 14 -4.74017
RNF167 ring finger protein 167 -4.69268
DCK deoxycytidine kinase -4.35437
KRT14 keratin 14, type I -3.6796
RNF111 ring finger protein 111 -3.46789
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -3.3371
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -3.27825
C1QBP complement component 1, q subcomponent binding protein -3.10419
SMC1A structural maintenance of chromosomes 1A -2.78407
DDRGK1 DDRGK domain containing 1 -2.78111
KDM5C lysine (K)-specific demethylase 5C -2.7504
POLR2M polymerase (RNA) II (DNA directed) polypeptide M -2.57577
GPR137B G protein-coupled receptor 137B -2.57073
CENPB centromere protein B, 80kDa -2.54582
ATRN attractin -2.53679
FPGS folylpolyglutamate synthase -2.51164
PUDP pseudouridine 5'-phosphatase -2.49356
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.48687
RAB38 RAB38, member RAS oncogene family -2.48092
RAI1 retinoic acid induced 1 -2.43705
TMED7 transmembrane emp24 protein transport domain containing 7 -2.33396
NSFL1C NSFL1 (p97) cofactor (p47) -2.31785
TMEM230 transmembrane protein 230 -2.29971
ANXA3 annexin A3 -2.29886
FKBP1C FK506 binding protein 1C -2.23239
HEATR1 HEAT repeat containing 1 -2.1895
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) -2.17798
INTS14 integrator complex subunit 14 -2.15598
ANPEP alanyl (membrane) aminopeptidase -2.12012
COL9A3 collagen, type IX, alpha 3 -2.10326
CD82 CD82 molecule -2.09586
NIBAN1 niban apoptosis regulator 1 -2.08124
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.08044
GPR183 G protein-coupled receptor 183 -2.05134
LRRC59 leucine rich repeat containing 59 -2.0243
NCOA4 nuclear receptor coactivator 4 -2.00417