CRCGN016_MCF10A.WT.HP_24H:L24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hydroxyprogesterone caproate 11.09 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

300 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:L24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
FHL2 four and a half LIM domains 2 6.52601
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 5.64926
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 5.47774
LRP10 low density lipoprotein receptor-related protein 10 4.88896
SYNGAP1 synaptic Ras GTPase activating protein 1 4.66436
AGR2 anterior gradient 2 4.54162
PPARG peroxisome proliferator-activated receptor gamma 4.50163
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 3.99551
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 3.97031
NUCB2 nucleobindin 2 3.966
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.8832
GPER1 G protein-coupled estrogen receptor 1 3.64947
DUSP4 dual specificity phosphatase 4 3.6343
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 3.43123
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.3512
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 3.32175
CHIC2 cysteine-rich hydrophobic domain 2 3.09398
CCDC92 coiled-coil domain containing 92 3.07159
IL1B interleukin 1, beta 3.02856
TM9SF3 transmembrane 9 superfamily member 3 3.00481
SNAP25 synaptosomal-associated protein, 25kDa 2.99545
DUSP6 dual specificity phosphatase 6 2.96098
PDIA5 protein disulfide isomerase family A, member 5 2.93841
ITGB5 integrin, beta 5 2.91927
PNKP polynucleotide kinase 3'-phosphatase 2.90964
GLRX glutaredoxin (thioltransferase) 2.8967
MAGED1 melanoma antigen family D1 2.87657
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.86756
SKIC2 SKI2 subunit of superkiller complex 2.85445
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.84537
MZT2B mitotic spindle organizing protein 2B 2.83306
IL4R interleukin 4 receptor 2.81574
GOLGB1 golgin B1 2.81054
IER3 immediate early response 3 2.79525
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.73865
TMEM214 transmembrane protein 214 2.73196
MZT2A mitotic spindle organizing protein 2A 2.68158
LIMA1 LIM domain and actin binding 1 2.64576
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.60245
GALE UDP-galactose-4-epimerase 2.58588
MAGED2 melanoma antigen family D2 2.57923
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 2.55143
GOLGA3 golgin A3 2.53893
NRIP1 nuclear receptor interacting protein 1 2.5315
PGM1 phosphoglucomutase 1 2.49748
VAT1 vesicle amine transport 1 2.48954
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.48479
QSOX1 quiescin Q6 sulfhydryl oxidase 1 2.47193
TRIOBP TRIO and F-actin binding protein 2.46373
CKAP5 cytoskeleton associated protein 5 2.44834
KLHDC2 kelch domain containing 2 2.40628
SMAD3 SMAD family member 3 2.40205
SIL1 SIL1 nucleotide exchange factor 2.40122
CSNK1E casein kinase 1, epsilon 2.39477
STX1A syntaxin 1A (brain) 2.3872
STXBP2 syntaxin binding protein 2 2.38681
TTC3 tetratricopeptide repeat domain 3 2.36961
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 2.36863
CALU calumenin 2.34495
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.34189
COPB1 coatomer protein complex, subunit beta 1 2.32441
ATXN2 ataxin 2 2.32012
VGLL4 vestigial-like family member 4 2.31738
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 2.30756
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 2.30598
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 2.30528
TRIB1 tribbles pseudokinase 1 2.29683
PSD3 pleckstrin and Sec7 domain containing 3 2.2937
SQOR sulfide quinone oxidoreductase 2.29116
TMEM184B transmembrane protein 184B 2.28422
HDLBP high density lipoprotein binding protein 2.28414
CAMTA2 calmodulin binding transcription activator 2 2.27804
SDC4 syndecan 4 2.26135
TPD52L2 tumor protein D52-like 2 2.22055
FURIN furin (paired basic amino acid cleaving enzyme) 2.2147
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 2.19763
RALGDS ral guanine nucleotide dissociation stimulator 2.19579
KCTD5 potassium channel tetramerization domain containing 5 2.19314
CENPE centromere protein E, 312kDa 2.17748
ACADVL acyl-CoA dehydrogenase, very long chain 2.17398
ATOSB atos homolog B 2.17167
TSC22D4 TSC22 domain family, member 4 2.16874
ADIPOR2 adiponectin receptor 2 2.16684
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 2.15706
SUN2 Sad1 and UNC84 domain containing 2 2.15619
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 2.1551
ATP9A ATPase, class II, type 9A 2.1493
IL1A interleukin 1, alpha 2.13002
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 2.12703
MVP major vault protein 2.1214
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 2.11719
ZNF451 zinc finger protein 451 2.10951
NT5E 5'-nucleotidase, ecto (CD73) 2.10505
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 2.08682
NTM neurotrimin 2.08665
PURA purine-rich element binding protein A 2.08544
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 2.08382
SEC16A SEC16 homolog A (S. cerevisiae) 2.08008
EPN2 epsin 2 2.07064
AFTPH aftiphilin 2.06787
STAP2 signal transducing adaptor family member 2 2.05868
FRYL FRY-like 2.05474
SSH3 slingshot protein phosphatase 3 2.04847
DPP8 dipeptidyl-peptidase 8 2.02772
STAMBP STAM binding protein 2.02719
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.02641
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 2.01437
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 2.00237
UBA7 ubiquitin-like modifier activating enzyme 7 2.00222
PYGL phosphorylase, glycogen, liver 2.00137
NDEL1 nudE neurodevelopment protein 1-like 1 2.00117

decreased expression

Symbol Name Standardized Value
SGK1 serum/glucocorticoid regulated kinase 1 -6.08959
S100A8 S100 calcium binding protein A8 -5.43906
C1QBP complement component 1, q subcomponent binding protein -5.12337
RGS2 regulator of G-protein signaling 2 -4.95494
NSDHL NAD(P) dependent steroid dehydrogenase-like -4.82717
MSMO1 methylsterol monooxygenase 1 -4.77454
TSC22D3 TSC22 domain family, member 3 -4.7418
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.37493
ADRB2 adrenoceptor beta 2, surface -4.36567
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -4.14642
LAP3 leucine aminopeptidase 3 -4.06298
FAIM Fas apoptotic inhibitory molecule -3.78165
CD320 CD320 molecule -3.69784
RPP40 ribonuclease P/MRP 40kDa subunit -3.58427
BPHL biphenyl hydrolase-like (serine hydrolase) -3.50117
ARID4B AT rich interactive domain 4B (RBP1-like) -3.48728
PRR15L proline rich 15-like -3.4737
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.38624
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.32442
ABT1 activator of basal transcription 1 -3.2971
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 -3.24941
INSIG1 insulin induced gene 1 -3.22428
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -3.16717
RPUSD2 RNA pseudouridylate synthase domain containing 2 -3.15886
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -3.15081
CYCS cytochrome c, somatic -3.13388
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 -3.07763
SPATA5L1 spermatogenesis associated 5-like 1 -3.07051
THUMPD2 THUMP domain containing 2 -3.01586
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.96663
TES testin LIM domain protein -2.9505
SDHAF3 succinate dehydrogenase complex assembly factor 3 -2.9461
DERA deoxyribose-phosphate aldolase (putative) -2.94544
NFIL3 nuclear factor, interleukin 3 regulated -2.93507
BAG3 BCL2-associated athanogene 3 -2.91475
ZNHIT2 zinc finger, HIT-type containing 2 -2.87161
GMNN geminin, DNA replication inhibitor -2.86723
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.85941
PYDC1 PYD (pyrin domain) containing 1 -2.83505
LIAS lipoic acid synthetase -2.83271
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 -2.83083
ZNF589 zinc finger protein 589 -2.77092
PRPF4 pre-mRNA processing factor 4 -2.75841
NLRP2B NLR family pyrin domain containing 2B -2.72865
SMNDC1 survival motor neuron domain containing 1 -2.70792
OIP5 Opa interacting protein 5 -2.67598
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.65928
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) -2.65317
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 -2.64692
DSCC1 DNA replication and sister chromatid cohesion 1 -2.63161
VCPKMT valosin containing protein lysine (K) methyltransferase -2.59291
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 -2.58566
GADD45B growth arrest and DNA-damage-inducible, beta -2.58436
STX17 syntaxin 17 -2.58314
CGRRF1 cell growth regulator with ring finger domain 1 -2.57786
GRPEL1 GrpE-like 1, mitochondrial (E. coli) -2.57464
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) -2.57451
DCN decorin -2.54874
TEX10 testis expressed 10 -2.54695
SH3D19 SH3 domain containing 19 -2.5436
MYNN myoneurin -2.53049
MYZAP myocardial zonula adherens protein -2.51991
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 -2.51704
LYPLA1 lysophospholipase I -2.50363
WDR73 WD repeat domain 73 -2.50071
PUS1 pseudouridylate synthase 1 -2.4737
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B -2.47252
NUP160 nucleoporin 160kDa -2.47089
NOP14 NOP14 nucleolar protein -2.4658
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) -2.44116
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) -2.43944
CD48 CD48 molecule -2.43337
EXOSC8 exosome component 8 -2.43244
CCDC86 coiled-coil domain containing 86 -2.41753
FKBP5 FK506 binding protein 5 -2.4038
METTL16 methyltransferase like 16 -2.39795
NOP16 NOP16 nucleolar protein -2.39551
VASH2 vasohibin 2 -2.3913
EMC8 ER membrane protein complex subunit 8 -2.38682
MRPL15 mitochondrial ribosomal protein L15 -2.37664
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.37416
PAK1IP1 PAK1 interacting protein 1 -2.36069
SLBP stem-loop binding protein -2.34835
MAIP1 matrix AAA peptidase interacting protein 1 -2.34584
SOAT2 sterol O-acyltransferase 2 -2.34524
CIAO2B cytosolic iron-sulfur assembly component 2B -2.3288
DDX49 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 -2.32192
CEP70 centrosomal protein 70kDa -2.3196
ILF2 interleukin enhancer binding factor 2 -2.31807
TMEM109 transmembrane protein 109 -2.30017
LETM1 leucine zipper-EF-hand containing transmembrane protein 1 -2.2989
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 -2.29742
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough -2.28803
NDC1 NDC1 transmembrane nucleoporin -2.28222
IPO4 importin 4 -2.27544
PLAAT2 phospholipase A and acyltransferase 2 -2.27488
SESN1 sestrin 1 -2.27121
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -2.26224
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) -2.25895
MED28 mediator complex subunit 28 -2.25287
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) -2.24286
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.24111
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.24049
TRAPPC8 trafficking protein particle complex 8 -2.2386
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 -2.23714
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) -2.23507
SETD4 SET domain containing 4 -2.2321
PSME3IP1 proteasome activator subunit 3 interacting protein 1 -2.23185
PRCP prolylcarboxypeptidase (angiotensinase C) -2.23016
ANKRD49 ankyrin repeat domain 49 -2.22751
HAUS3 HAUS augmin-like complex, subunit 3 -2.2258
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 -2.22571
GINS2 GINS complex subunit 2 (Psf2 homolog) -2.21556
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.21333
MRPL44 mitochondrial ribosomal protein L44 -2.20321
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein -2.20078
ADI1 acireductone dioxygenase 1 -2.20038
GBP1 guanylate binding protein 1, interferon-inducible -2.19904
ZBTB39 zinc finger and BTB domain containing 39 -2.19849
ANXA2 annexin A2 -2.19328
TARBP2 TAR (HIV-1) RNA binding protein 2 -2.19265
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 -2.1867
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.18506
HEATR3 HEAT repeat containing 3 -2.18264
GPR65 G protein-coupled receptor 65 -2.18105
MTERF3 mitochondrial transcription termination factor 3 -2.17962
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 -2.17763
WDR43 WD repeat domain 43 -2.17407
HADH hydroxyacyl-CoA dehydrogenase -2.17157
TMEM33 transmembrane protein 33 -2.16055
BRIX1 BRX1, biogenesis of ribosomes -2.16052
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -2.15872
ARL4A ADP-ribosylation factor-like 4A -2.15285
PRMT5 protein arginine methyltransferase 5 -2.15147
FECH ferrochelatase -2.1465
TMX2 thioredoxin-related transmembrane protein 2 -2.14646
MCMBP minichromosome maintenance complex binding protein -2.14562
DCAF17 DDB1 and CUL4 associated factor 17 -2.14545
BTK Bruton agammaglobulinemia tyrosine kinase -2.14381
GTPBP8 GTP-binding protein 8 (putative) -2.13967
EXOSC5 exosome component 5 -2.13359
HINFP histone H4 transcription factor -2.13128
GLUL glutamate-ammonia ligase -2.1168
ASPN asporin -2.11234
PTGES3 prostaglandin E synthase 3 (cytosolic) -2.10573
C18ORF25 chromosome 18 open reading frame 25 -2.10469
GCH1 GTP cyclohydrolase 1 -2.10262
TRDMT1 tRNA aspartic acid methyltransferase 1 -2.10173
LMNB1 lamin B1 -2.09936
EVI2B ecotropic viral integration site 2B -2.09622
MAD2L1BP MAD2L1 binding protein -2.08992
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A -2.08902
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.08626
EIF3J eukaryotic translation initiation factor 3, subunit J -2.08599
POLR1D polymerase (RNA) I polypeptide D, 16kDa -2.08418
TEFM transcription elongation factor, mitochondrial -2.08307
STARD5 StAR-related lipid transfer (START) domain containing 5 -2.08079
WDR70 WD repeat domain 70 -2.08034
USP39 ubiquitin specific peptidase 39 -2.0767
SETD6 SET domain containing 6 -2.07412
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit -2.07206
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -2.06858
SAXO6 stabilizer of axonemal microtubules 6 -2.0649
CLEC7A C-type lectin domain family 7, member A -2.06451
POLD1 polymerase (DNA directed), delta 1, catalytic subunit -2.06338
HIKESHI heat shock protein nuclear import factor hikeshi -2.06147
KAT2A K(lysine) acetyltransferase 2A -2.05879
WNT2 wingless-type MMTV integration site family member 2 -2.05534
SLC35A5 solute carrier family 35, member A5 -2.05359
DEPTOR DEP domain containing MTOR-interacting protein -2.05309
TOE1 target of EGR1, member 1 (nuclear) -2.05075
CXCL10 chemokine (C-X-C motif) ligand 10 -2.04839
GINS3 GINS complex subunit 3 (Psf3 homolog) -2.04659
TFEC transcription factor EC -2.04619
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 -2.04553
RAD54L RAD54-like (S. cerevisiae) -2.03544
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1 -2.03498
SLC35B1 solute carrier family 35, member B1 -2.03125
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 -2.03011
DNA2 DNA replication helicase/nuclease 2 -2.02389
MCAT malonyl CoA:ACP acyltransferase (mitochondrial) -2.02111
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) -2.0197
ERCC6L excision repair cross-complementation group 6-like -2.0157
MCM4 minichromosome maintenance complex component 4 -2.01419
MRPL48 mitochondrial ribosomal protein L48 -2.00814
POLR2D polymerase (RNA) II (DNA directed) polypeptide D -2.00603
OXA1L oxidase (cytochrome c) assembly 1-like -2.00417
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.0014
LIN9 lin-9 DREAM MuvB core complex component -2.00138