CRCGN016_MCF10A.WT.HP_24H:M05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description bis(chloromethyl) ether 33.43 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

79 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:M05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 5.81224
LOXL1 lysyl oxidase-like 1 5.12054
COMP cartilage oligomeric matrix protein 4.2159
AGR2 anterior gradient 2 3.26676
ACAA1 acetyl-CoA acyltransferase 1 3.10597
WFS1 Wolfram syndrome 1 (wolframin) 2.98299
HBA1 hemoglobin, alpha 1 2.87409
CCNA1 cyclin A1 2.7951
FPGS folylpolyglutamate synthase 2.6946
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.66583
ZNF451 zinc finger protein 451 2.62476
TBPL1 TBP-like 1 2.57966
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2.52457
IFT52 intraflagellar transport 52 2.48617
CD48 CD48 molecule 2.44689
IRAK4 interleukin-1 receptor-associated kinase 4 2.35198
EPS8 epidermal growth factor receptor pathway substrate 8 2.24751
ZDHHC4 zinc finger, DHHC-type containing 4 2.23783
SNX13 sorting nexin 13 2.2112
C3AR1 complement component 3a receptor 1 2.17873
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.12481
F13A1 coagulation factor XIII, A1 polypeptide 2.12157
RMDN3 regulator of microtubule dynamics 3 2.11764
CD53 CD53 molecule 2.11513
CLXN calaxin 2.00053

decreased expression

Symbol Name Standardized Value
BASP1 brain abundant, membrane attached signal protein 1 -8.02222
CANT1 calcium activated nucleotidase 1 -6.42318
HMG20B high mobility group 20B -4.98695
PLK1 polo-like kinase 1 -4.81287
TUBB6 tubulin, beta 6 class V -4.36943
GDF15 growth differentiation factor 15 -4.21301
PCNA proliferating cell nuclear antigen -4.17827
ANXA2 annexin A2 -4.10201
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.89505
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.69441
PPIC peptidylprolyl isomerase C (cyclophilin C) -3.59441
CTNND1 catenin (cadherin-associated protein), delta 1 -3.55941
MELK maternal embryonic leucine zipper kinase -3.52434
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -3.44618
CREG1 cellular repressor of E1A-stimulated genes 1 -3.18646
CNPY3 canopy FGF signaling regulator 3 -3.00517
RNPS1 RNA binding protein S1, serine-rich domain -2.99309
LYPLA1 lysophospholipase I -2.98246
PFN1 profilin 1 -2.79319
TGIF1 TGFB-induced factor homeobox 1 -2.76251
SNRPA small nuclear ribonucleoprotein polypeptide A -2.65999
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -2.62487
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -2.62368
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.61267
SLC75A1 solute carrier family 75 member 1 -2.57131
TUSC3 tumor suppressor candidate 3 -2.54205
FKBP1C FK506 binding protein 1C -2.46527
DUSP14 dual specificity phosphatase 14 -2.43467
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -2.37413
ENO3 enolase 3 (beta, muscle) -2.36238
RHOBTB2 Rho-related BTB domain containing 2 -2.34236
RXYLT1 ribitol xylosyltransferase 1 -2.33877
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase -2.33011
UNC13B unc-13 homolog B (C. elegans) -2.287
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.25624
VCP valosin containing protein -2.22372
AKAP8 A kinase (PRKA) anchor protein 8 -2.22046
RCOR1 REST corepressor 1 -2.20627
ARID4B AT rich interactive domain 4B (RBP1-like) -2.17556
SEC23B Sec23 homolog B (S. cerevisiae) -2.15489
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.13825
PMF1-BGLAP PMF1-BGLAP readthrough -2.10823
FLRT3 fibronectin leucine rich transmembrane protein 3 -2.10332
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.09805
BDNF brain-derived neurotrophic factor -2.09163
LOC102724428 serine/threonine-protein kinase SIK1 -2.09021
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.0794
LASP1 LIM and SH3 protein 1 -2.06227
SPRED2 sprouty-related, EVH1 domain containing 2 -2.0567
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) -2.05388
TVP23B trans-golgi network vesicle protein 23 homolog B (S. cerevisiae) -2.05239
EIF5 eukaryotic translation initiation factor 5 -2.04908
DSG1 desmoglein 1 -2.01244
FAT1 FAT atypical cadherin 1 -2.00302